Wang Jun-Sheng, Newport D Jeffrey, Stowe Zachary N, Donovan Jennifer L, Pennell Page B, DeVane C Lindsay
Department of Psychiatry and Behavioral Sciences, and Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA.
Drug Metab Rev. 2007;39(4):723-46. doi: 10.1080/03602530701690390.
P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.
P-糖蛋白、乳腺癌耐药蛋白和多药耐药蛋白在胎盘组织中具有生理功能。已发现几种抗抑郁药、抗精神病药和抗癫痫药是P-糖蛋白及其他转运蛋白的底物。药物穿过胎盘屏障的程度可能受药物转运蛋白的影响。在为育龄期女性选择治疗精神疾病的精神活性药物时，应综合考虑药物处置情况及预期药理作用等知识。本综述总结了目前关于药物转运蛋白在药物胎盘转运方面的数据，重点关注临床精神药理学中使用的药物。
