Hufnagl P, Beil M, Wenzelides K, Martin H
Institut für Pathologie der Medizinischen Fakultät (Charité) der Humboldt-Universität zu Berlin, Deutschland.
Zentralbl Pathol. 1991;137(6):493-7.
Nucleolus organizer regions (NORs) are associated with proliferative activity of tumors. An image analysis method is presented in this paper by which it is possible to analyze NOR location within the nucleus and relative to each other. Several features which characterized locations were measured in 20 urinary bladder carcinomas, eight astrocytomas, and two glioblastomas. Correlations were found to exist between those features, on the one hand, and tumor malignancy, on the other. They were particularly close in astrocytoma. Mean distance among NORs and closeness to the nuclear membrane were found to increase, as well, along with aggravating malignancy. As to the urinary bladder carcinomas examined, an unambiguous difference was found to exist between G 1 and G 1-2 carcinomas.
核仁组织区（NORs）与肿瘤的增殖活性相关。本文提出了一种图像分析方法，通过该方法可以分析NOR在细胞核内的位置以及它们之间的相对位置。在20例膀胱癌、8例星形细胞瘤和2例胶质母细胞瘤中测量了表征位置的几个特征。一方面发现这些特征与肿瘤恶性程度之间存在相关性。它们在星形细胞瘤中尤其密切。还发现NORs之间的平均距离以及与核膜的接近程度也随着恶性程度的加重而增加。至于所检查的膀胱癌，在G1期和G1-2期癌之间发现了明确的差异。
