Pedal W P, Warzok R W, Hufnagl P, Roth K
Neurosurgical Department, University Clinic Benjamin Franklin, Free University of Berlin, Germany.
Clin Neuropathol. 1995 Jan-Feb;14(1):55-61.
Seventy-nine astrocytic tumors classified according to the WHO classification and stained with a modified AgNOR staining technique were analyzed with the help of an automatic image analyzing system. With increasing malignancy there is an increase of AgNORs per cell. Furthermore, AgNORs move from a more central to a more peripheral position within the nucleus, thus leading to a significant increase of the AgNOR count at the periphery of the nucleus. An inverse relation was found at the center. With regard to AgNORs, there are little differences between anaplastic astrocytomas and small cell glioblastomas. The most striking differences were seen between differentiated (grade 2) and anaplastic (grade 3) astrocytomas.
应用自动图像分析系统对79例根据世界卫生组织（WHO）分类法分类并用改良的核仁组成区嗜银蛋白（AgNOR）染色技术染色的星形细胞瘤进行分析。随着恶性程度的增加，每个细胞中的AgNOR数量增多。此外，AgNOR在细胞核内从更中央的位置移至更周边的位置，从而导致细胞核周边的AgNOR计数显著增加。在细胞核中央发现相反的关系。关于AgNOR，间变性星形细胞瘤和小细胞胶质母细胞瘤之间差异不大。在分化型（2级）和间变性（3级）星形细胞瘤之间观察到最显著的差异。
