Like A A, Rossini A A
Science. 1976 Jul 30;193(4251):415-7. doi: 10.1126/science.180605.
Multiple small injections of streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.
对小鼠多次小剂量注射链脲佐菌素会引发胰腺胰岛炎，进而发展为几乎完全的β细胞破坏和糖尿病。炎症性胰岛病变的发生时间和表现提示但未证实链脲佐菌素是通过引发细胞介导的免疫反应起作用的。在接受治疗的小鼠β细胞内存在大量C型病毒的超微结构证据表明，链脲佐菌素可能在易感宿主体内激活鼠白血病病毒。
