Bernades P, Le Tellier A, Dupuy R
Sem Hop. 1975 Jun 14;51(28):1935-9.
The efficacy of medical treatment was studied in 53 patients with a peptic ulcer responsible for disturbed gastric emptying. An improvement in gastric emptying was noted in 38 cases and persistence of the disorder in 15 cases. These results were not related to the dose of anticholinergic drug, nor to the degree of disturbance in gastric emptying. Only one improvement was noted out of 7 cases of pyloric ulcer. A relapse of disturbed gastric emptying, occurred in 17 out of 38 patients who were initially improved. 25 patients out of 53 were finally operated on, 15 owing to persistence of the gastric emptying disturbance under treatment and 10 owing to a relapse. Out of 18 gastrectomy specimens, the ulcer was found to be healed in 7 cases. It seems that disturbed gastric emptying may be due to fixed deformities of the pylorus which are little changed by medical treatment, and minor disturbances of emptying regress well under treatment. Disturbed gastric emptying due tp pyloric ulcer is the most difficult to treat medically.
对53例因消化性溃疡导致胃排空障碍的患者的药物治疗效果进行了研究。38例患者胃排空得到改善,15例患者胃排空障碍持续存在。这些结果与抗胆碱能药物的剂量无关,也与胃排空障碍的程度无关。7例幽门溃疡患者中仅1例得到改善。最初病情改善的38例患者中有17例出现胃排空障碍复发。53例患者中有25例最终接受了手术,15例是因为治疗期间胃排空障碍持续存在,10例是因为复发。在18份胃切除标本中,发现7例溃疡已愈合。胃排空障碍似乎可能是由于幽门固定性畸形所致,药物治疗对此改变不大,而轻度排空障碍在治疗下恢复良好。幽门溃疡导致的胃排空障碍最难通过药物治疗。