Stucker Sina, Chen Junyu, Watt Fiona E, Kusumbe Anjali P
Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2020 Nov 26;8:602269. doi: 10.3389/fcell.2020.602269. eCollection 2020.
The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The nurturing vascular niches in the BM are complex and heterogenous consisting of distinct vascular and perivascular cell types that provide crucial signals for the maintenance of stem and progenitor cells. Growing evidence suggests that the BM niche is highly sensitive to stress. Aging, inflammation and other stress factors induce changes in BM niche cells and their crosstalk with tissue cells leading to perturbed hematopoiesis, bone angiogenesis and bone formation. Defining vascular niche remodeling under stress conditions will improve our understanding of the BM vascular niche and its role in homeostasis and disease. Therefore, this review provides an overview of the current understanding of the BM vascular niches for hematopoietic stem cells and their malfunction during aging, bone loss diseases, arthritis and metastasis.
骨髓（BM）血管龛微环境中含有各种谱系的干细胞和祖细胞。骨血管生成具有独特性，涉及组织特异性信号。骨髓中滋养性血管龛复杂且异质，由不同的血管和血管周围细胞类型组成，这些细胞为干细胞和祖细胞的维持提供关键信号。越来越多的证据表明，骨髓龛对压力高度敏感。衰老、炎症和其他压力因素会诱导骨髓龛细胞发生变化以及它们与组织细胞的相互作用，从而导致造血功能紊乱、骨血管生成和骨形成异常。明确应激条件下血管龛的重塑将增进我们对骨髓血管龛及其在体内稳态和疾病中作用的理解。因此，本综述概述了目前对造血干细胞骨髓血管龛的认识及其在衰老、骨质流失疾病、关节炎和转移过程中的功能障碍。
