干扰素诱导的抗病毒蛋白的Mx GTP酶家族。
The Mx GTPase family of interferon-induced antiviral proteins.
作者信息
Haller Otto, Stertz Silke, Kochs Georg
机构信息
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herderstrasse 11, D-79008 Freiburg, Germany.
出版信息
Microbes Infect. 2007 Nov-Dec;9(14-15):1636-43. doi: 10.1016/j.micinf.2007.09.010. Epub 2007 Sep 14.
PMID:18062906
Abstract
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.
摘要
Mx蛋白是由干扰素诱导产生的大GTP酶动力蛋白超家族成员。它们通过阻断复制周期的早期阶段来抑制多种病毒。对基因定义的小鼠品系的研究突出了它们在早期抗病毒宿主防御中的强大作用。
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