伊朗西南部胡齐斯坦省献血者中戊型肝炎病毒的血清流行率。
Seroprevalence of hepatitis E virus in blood donors in Khuzestan Province, southwest Iran.
作者信息
Assarehzadegan Mohammad Ali, Shakerinejad Ghodratollah, Amini Akram, Rezaee S A Rahim
机构信息
Department of Immunology, Faculty of Medicine, Ahwaz Joundishapur University of Medical Sciences, Ahwaz, Iran.
出版信息
Int J Infect Dis. 2008 Jul;12(4):387-90. doi: 10.1016/j.ijid.2007.09.015. Epub 2007 Dec 11.
OBJECTIVE
To determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors in Khuzestan Province, Iran. Khuzestan is a war stricken area in the southwest of Iran, which shares a land, river, and sea border with Iraq. This region has suffered the heaviest public health system damage of all the Iranian provinces during a 25-year period of war and conflict.
METHODS
A cross-sectional study was carried out among 400 urban volunteer blood donors of the regional blood banks, from May to December 2005. Serum samples from healthy blood donors were tested for IgG anti-HEV antibody using a specific enzyme linked immunoassay (ELISA) kit.
RESULTS
The prevalence of HEV infection was found to be 11.5% (46/400). All patients were negative for anti-HIV, anti-HBV, and anti-HCV antibodies. The data indicate that 14.6% (38/260) of HEV positive subjects were male, compared to 5.7% (8/140) of females; this difference is statistically significant (risk ratio=2.6, p<0.008).
CONCLUSIONS
These findings demonstrate the high prevalence rate of anti-HEV among blood donors, particularly males.
目的
确定伊朗胡齐斯坦省志愿献血者中戊型肝炎病毒（HEV）感染的血清流行率。胡齐斯坦是伊朗西南部一个饱受战争蹂躏的地区，与伊拉克接壤，有陆地、河流和海洋边界。在长达25年的战争和冲突期间，该地区是伊朗所有省份中公共卫生系统受损最严重的地区。
方法
2005年5月至12月，对该地区血库的400名城市志愿献血者进行了一项横断面研究。使用特定的酶联免疫吸附测定（ELISA）试剂盒对健康献血者的血清样本进行IgG抗HEV抗体检测。
结果
发现HEV感染率为11.5%（46/400）。所有患者的抗HIV、抗HBV和抗HCV抗体均为阴性。数据表明，HEV阳性受试者中14.6%（38/260）为男性，而女性为5.7%（8/140）；这种差异具有统计学意义（风险比=2.6，p<0.008）。
结论
这些发现表明献血者中抗HEV的流行率很高，尤其是男性。
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