Ahmed Azza Masoud Abdelbaky, Temerk Hanan Abdelftah, Galal Hamdi Ramdan, Bazeed Shamardan Ezzeldin S, Sultan Serageldeen
Department of Microbiology, Virology Division, Faculty of Veterinary Medicine, South Valley University, 83523 Qena, Egypt.
National Blood Bank Services, Qena, Egypt.
Virusdisease. 2020 Sep;31(3):292-298. doi: 10.1007/s13337-020-00589-9. Epub 2020 May 5.
This study was performed to determine the prevalence of HBV and HCV infection among blood donors and the occurrence of HEV in hepatitis viruses seropositive blood donors. Also, to investigate the correlation between the occurrence of hepatitis viruses and other risk factors (gender, age, occupation, educational level, residency and donors' types). A total of 11,604 blood samples from apparently healthy blood donors of age range 18-60 years old were collected. The blood donors were categorized as voluntary and replacement donors. Blood samples from donors were tested for the presence of HBsAg, HCV and HEV antibodies by using Enzyme-linked immunosorbent assay. The overall results indicated that 671 out of 11,604 blood donors; 370 persons (3.188%) HCV, 295 persons (2.542%) HBV and 6 persons (0.052%) HCV and HBV; were hepatitis viruses seropositive donors. The prevalence of HEV were 193 (28.76%) among these seropositive blood donors. There is a highly significant correlation among HCV, HBV and other risk factors. Also, the HEV showed high significant with age and educational level and significant with donor types and locations. All investigated virus combinations (HEV/HCV, HEV/HBV and HEV/HCV/HBV) were highly significant with the risk factors except for occupation. In conclusion, the HEV is significantly correlated to HCV and HBV seropositive donors and should be screened among blood donors.
本研究旨在确定献血者中乙肝病毒（HBV）和丙肝病毒（HCV）感染的流行情况，以及戊型肝炎病毒（HEV）在肝炎病毒血清学阳性献血者中的发生情况。此外，还研究肝炎病毒的发生与其他风险因素（性别、年龄、职业、教育程度、居住地和献血者类型）之间的相关性。共收集了11604份年龄在18至60岁之间表面健康的献血者的血样。献血者分为自愿献血者和替代献血者。使用酶联免疫吸附测定法检测献血者血样中HBsAg、HCV和HEV抗体的存在情况。总体结果显示，在11604名献血者中，有671人；370人（3.188%）感染HCV，295人（2.542%）感染HBV，6人（0.052%）同时感染HCV和HBV；为肝炎病毒血清学阳性献血者。在这些血清学阳性献血者中，HEV的流行率为193人（28.76%）。HCV、HBV与其他风险因素之间存在高度显著的相关性。此外，HEV与年龄和教育程度高度显著相关，与献血者类型和地点显著相关。除职业外，所有研究的病毒组合（HEV/HCV、HEV/HBV和HEV/HCV/HBV）与风险因素均高度显著相关。总之，HEV与HCV和HBV血清学阳性献血者显著相关，应在献血者中进行筛查。
