Jensen Majken K, Mukamal Kenneth J, Overvad Kim, Rimm Eric B
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Eur Heart J. 2008 Jan;29(1):104-12. doi: 10.1093/eurheartj/ehm517. Epub 2007 Dec 6.
To investigate whether a common polymorphism in the cholesteryl ester transfer protein (CETP) gene modifies the relationship of alcohol intake with high-density lipoprotein cholesterol (HDL-C) and risk of coronary heart disease (CHD).
Parallel nested case-control studies among women [Nurses' Health Study (NHS)] and men [Health Professionals Follow-up Study (HPFS)] where 246 women and 259 men who developed incident CHD were matched to controls (1:2) on age and smoking. The TaqIB variant and alcohol consumption were associated with higher HDL-C, with the most pronounced effects of alcohol among B2 carriers. In the NHS we did not find an inverse association between alcohol and CHD in B2 non-carriers (P trend: 0.5), but did among B2 carriers (P trend <0.01). Among non-carriers the odds ratio (OR) for CHD among women with an intake of 5-14 g/day was 1.4 (95% CI: 0.6-3.7) compared with non-drinkers, whereas among B2 carriers the OR was 0.4 (0.2-0.8). Results in men were less suggestive of an interaction; corresponding OR's were 1.9 (0.8-4.5) and 0.9 (0.5-1.6), for B2 non-carriers and carriers, respectively.
The association of alcohol with HDL-C levels was modified by CETP TaqIB2 carrier status, and there was also a suggestion of a gene-environment interaction on the risk of CHD.
研究胆固醇酯转运蛋白（CETP）基因中的一种常见多态性是否会改变酒精摄入量与高密度脂蛋白胆固醇（HDL-C）以及冠心病（CHD）风险之间的关系。
在女性[护士健康研究（NHS）]和男性[卫生专业人员随访研究（HPFS）]中进行平行嵌套病例对照研究，将246例发生冠心病的女性和259例男性与年龄和吸烟情况相匹配的对照（1:2）进行配对。TaqIB变异体和酒精消费与较高的HDL-C相关，酒精对B2携带者的影响最为显著。在NHS中，我们未发现B2非携带者中酒精与冠心病之间存在负相关（P趋势：0.5），但在B2携带者中发现了这种负相关（P趋势<0.01）。在非携带者中，每天摄入5 - 14克酒精的女性患冠心病的比值比（OR）为1.4（95%可信区间：0.6 - 3.7），而在B2携带者中，OR为0.4（0.2 - 0.8）。男性的结果不太提示存在相互作用；B2非携带者和携带者的相应OR分别为1.9（0.8 - 4.5）和0.9（0.5 - 1.6）。
CETP TaqIB2携带者状态改变了酒精与HDL-C水平之间的关联，并且也提示在冠心病风险方面存在基因 - 环境相互作用。
