Murua V S, Molina V A
Facultad de Filosofia y Humanidades, Universidad Nacional de Cordoba, Argentina.
Eur J Pharmacol. 1991 Nov 5;204(2):187-92. doi: 10.1016/0014-2999(91)90704-t.
The occurrence of inactivity during inescapable shock is a good predictor of escape deficit because a positive correlation was obtained between the two factors. Chronic desipramine (DMI) administration prior to inescapable shock clearly reduced the inactivity during this aversive experience. Moreover, repeated DMI administration either before or after inescapable shock reversed the increase, in escape failures and in inactivity during shuttle-box testing produced by this inescapable shock. A single injection with DMI before either inescapable shock or shuttle-box test altered neither inactivity nor escape deficit. Clomipramine and phenelzine were also effective to reduce inactivity and escape failures. However, other drugs without antidepressant properties, such as haloperidol, amphetamine, and diazepam reduced neither inactivity nor escape deficit. These data suggest that an anti-inactivity effect is critically involved in the reversal of inescapable shock-induced escape deficit following chronic antidepressants. The involvement of antidepressant-induced changes in beta-adrenoceptors with this behavioral reversal is discussed.
在不可逃避电击期间出现的静止不动是逃避缺陷的良好预测指标，因为这两个因素之间存在正相关。在不可逃避电击前长期给予地昔帕明（DMI）可明显减少这种厌恶体验期间的静止不动。此外，在不可逃避电击之前或之后反复给予DMI可逆转由这种不可逃避电击在穿梭箱测试中导致的逃避失败及静止不动次数的增加。在不可逃避电击或穿梭箱测试前单次注射DMI，既不改变静止不动情况，也不改变逃避缺陷。氯米帕明和苯乙肼也可有效减少静止不动及逃避失败。然而，其他无抗抑郁特性的药物，如氟哌啶醇、苯丙胺和地西泮，既不减少静止不动，也不减少逃避缺陷。这些数据表明，抗静止不动效应在慢性抗抑郁药逆转不可逃避电击诱导的逃避缺陷中起关键作用。文中还讨论了抗抑郁药诱导的β-肾上腺素能受体变化与这种行为逆转的关系。
