Kotaska Karel, Petrak Borivoj, Kukacka Jiri, Kraus Josef, Prusa Richard
Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
Neuro Endocrinol Lett. 2007 Dec;28(6):761-4.
The aim of the study was to investigate the relationship of serum levels of neuron-specific enolase, anti-vimentin IgG, and anti-vimentin IgM antibodies in patients with neurofibromatosis type 1 and associated tumors (optic glioma, and plexiform neurofibroma).
Measurement of neuron-specific enolase and anti-vimentin antibodies were performed in 131 children and adolescents (67 males, mean age 10 years, range 4-19 years; 64 females, mean age 11 years, range 1-20 years) with three different forms of neurofibromatosis type 1 and in control group of 40 individuals (20 males, mean age 9 years, range 1-19 years and 20 females, mean age 12 years, range 3-18 years).
Anti-vimentin IgG, IgM antibodies and NSE showed similar ability to distinguish between neurofibromatosis type 1 and tumors associated with neurofibromatosis type 1. (AUC=0.57, AUC=0.52 and AUC=0.59 respectively). NSE showed better diagnostic efficiency (AUC=0.68) than the anti-vimentin IgG and anti-vimentin IgM. (AUC=0.63 and AUC=0.56 respectively). Anti-vimentin IgG and IgM antibodies showed higher sensitivity (87.5% and 87.2%) at the cut off value than the NSE (54%). On the contrary, NSE showed higher specificity at the cut off value than both the anti-vimentin IgG and IgM (71% vs. 22.5% and 16% respectively).
Anti-vimentin IgG and IgM and neuron-specific enolase are relevant markers in investigation of the patients with neurofibromatosis type 1 and associated tumors.
本研究旨在调查1型神经纤维瘤病患者及相关肿瘤（视神经胶质瘤和丛状神经纤维瘤）血清中神经元特异性烯醇化酶、抗波形蛋白IgG和抗波形蛋白IgM抗体水平之间的关系。
对131名患有三种不同形式1型神经纤维瘤病的儿童和青少年（67名男性，平均年龄10岁，范围4 - 19岁；64名女性，平均年龄11岁，范围1 - 20岁）以及40名个体组成的对照组（20名男性，平均年龄9岁，范围1 - 19岁；20名女性，平均年龄12岁，范围3 - 18岁）进行神经元特异性烯醇化酶和抗波形蛋白抗体的检测。
抗波形蛋白IgG、IgM抗体和NSE在区分1型神经纤维瘤病和与1型神经纤维瘤病相关的肿瘤方面表现出相似的能力。（曲线下面积分别为0.57、0.52和0.59）。NSE显示出比抗波形蛋白IgG和抗波形蛋白IgM更好的诊断效率（曲线下面积分别为0.68、0.63和0.56）。抗波形蛋白IgG和IgM抗体在临界值时的敏感性（分别为87.5%和87.2%）高于NSE（54%）。相反，NSE在临界值时的特异性高于抗波形蛋白IgG和IgM两者（分别为71%对22.5%和16%）。
抗波形蛋白IgG和IgM以及神经元特异性烯醇化酶是1型神经纤维瘤病及相关肿瘤患者研究中的相关标志物。
