Pelling Andrew E, Horton Michael A
The London Centre for Nanotechnology, Centre for Nanomedicine, University College London, 17-19 Gordon Street, London WC1H 0AH, UK.
Pflugers Arch. 2008 Apr;456(1):3-12. doi: 10.1007/s00424-007-0405-1. Epub 2007 Dec 7.
The physical properties of the protoplasm have long been of interest, and today, several intricate methods, including atomic force microscopy, have been employed in studies of cellular mechanics. However, many current concepts and experimental approaches actually have their beginnings over 300 years ago. Unfortunately, these pioneering studies have been all but forgotten. In this paper, we have reviewed some of the early literature on cellular mechanics to place modern work within an historical framework. It is clear that with current nanoscience approaches, modern experiments employing cell indentation, manipulation, particle rheology and micro- or nano-needle poking are now quantifying mechanical properties which were only qualitatively described 100 years ago. Aside from the variety of approaches our predecessors have employed to understand cellular mechanics, we feel an understanding of the past will help to propel nanoscience into the future. As nanophysiology and nanomedicine are developing, we as a community should take time to consider the early roots of these fields.
原生质的物理特性长期以来一直备受关注，如今，包括原子力显微镜在内的几种复杂方法已被用于细胞力学研究。然而，许多当前的概念和实验方法实际上始于300多年前。不幸的是，这些开创性研究几乎已被遗忘。在本文中，我们回顾了一些关于细胞力学的早期文献，以便将现代研究置于历史框架之中。很明显，借助当前的纳米科学方法，采用细胞压痕、操纵、颗粒流变学以及微针或纳米针刺入等现代实验正在对100年前仅作定性描述的力学特性进行量化。除了我们的前辈用于理解细胞力学的各种方法外，我们认为了解过去将有助于推动纳米科学走向未来。随着纳米生理学和纳米医学的发展，作为一个群体，我们应该花时间思考这些领域的早期根源。
