Clinical Insights, Ltd, 60 Summer Duck Way, Pittsburgh, PA 15238.
Department of Chemical Engineering, Carnegie Mellon University, Doherty Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213; Forensics Department, Thornton Tomasetti, 120 Broadway 15th Floor, New York City, NY 10271.
J Biomech Eng. 2022 Aug 1;144(8). doi: 10.1115/1.4053797.
The 2021 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) featured a workshop titled "The Elephant in the Room: Nuclear Mechanics and Mechanobiology." The goal of this workshop was to provide a perspective from experts in the field on the current understanding of nuclear mechanics and its role in mechanobiology. This paper reviews the major themes and questions discussed during the workshop, including historical context on the initial methods of measuring the mechanical properties of the nucleus and classifying the primary structures dictating nuclear mechanics, physical plasticity of the nucleus, the emerging role of the linker of nucleoskeleton and cytoskeleton (LINC) complex in coupling the nucleus to the cytoplasm and driving the behavior of individual cells and multicellular assemblies, and the computational models currently in use to investigate the mechanisms of gene expression and cell signaling. Ongoing questions and controversies, along with promising future directions, are also discussed.
2021 年夏生物力学、生物工程和生物传输会议（SB3C）的一个特色是举办了一场题为“房间里的大象：核力学和机械生物学”的研讨会。本次研讨会的目标是从该领域的专家那里提供对核力学当前理解及其在机械生物学中的作用的观点。本文回顾了研讨会期间讨论的主要主题和问题，包括最初用于测量核机械性能并对决定核力学的主要结构进行分类的方法的历史背景、核的物理可塑性、核骨架和细胞骨架连接体（LINC）复合物在将核与细胞质连接并驱动单个细胞和多细胞组合行为方面的新兴作用，以及目前用于研究基因表达和细胞信号转导机制的计算模型。还讨论了正在出现的问题和争议，以及有前途的未来方向。
