Warner Justin T
Department of Child Health, University Hospital of Wales, Cardiff, Wales, UK.
Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):456-61; discussion 468. doi: 10.1002/pbc.21411.
Survivors of acute lymphoblastic leukaemia (ALL) are recognised to become overweight and this seems to worsen with increasing length of follow up. Increases in body fat appear to be more marked in girls than in boys and in those who have received prophylactic cranial irradiation. Physiological responses to exercise, both at submaximal and maximal levels, are different in ALL survivors compared to controls. Heart rate appears to be increased at low intensity exercise, possibly to maintain adequate cardiac output. Maximal aerobic capacity is reduced, signifying a lower level of physical fitness. Total daily energy expenditure (TDEE) under free living conditions appears limited due to low participation in physical activity. Associations exist between measures of energy expenditure and body fat, but whether these are cause or effect has yet to proven.
急性淋巴细胞白血病（ALL）幸存者被认为会超重，而且随着随访时间的延长，这种情况似乎会恶化。女孩的体脂增加似乎比男孩更明显，在接受预防性颅脑照射的患者中也是如此。与对照组相比，ALL幸存者在次最大和最大运动水平下的生理反应有所不同。在低强度运动时心率似乎会增加，可能是为了维持足够的心输出量。最大有氧能力降低，表明身体素质较低。由于体力活动参与度低，自由生活条件下的每日总能量消耗（TDEE）似乎有限。能量消耗指标与体脂之间存在关联，但这些是因果关系还是其他关系尚待证实。
