Haug Line S, Thomsen Cathrine, Liane Veronica H, Becher Georg
Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
Chemosphere. 2008 Apr;71(6):1087-92. doi: 10.1016/j.chemosphere.2007.10.044. Epub 2007 Dec 11.
In order to assess the quality and comparability of results from determinations of 1,2,5,6,9,10-hexabromocyclododecane (HBCD) in biological samples, two interlaboratory comparison studies have been organized. Up to 13 laboratories determined either the total HBCD concentration, or concentrations of alpha-, beta- and gamma-HBCD, or both in cod liver oil, herring filet, salmon filet, butter and chicken meat. The laboratories were able to determine total HBCD concentrations in the marine samples with satisfying quality (RSD <35%). However, the analysis of samples with low HBCD contamination (<about 2ngg(-1) lipid weight) should be improved. No statistically significant differences were found between total HBCD concentrations obtained by LC-MS and GC-MS. To our knowledge, this is the first report on interlaboratory comparison studies concerning the determination of HBCD in biological samples comprising results from a sufficient number of participants to perform a statistical evaluation.
为评估生物样品中1,2,5,6,9,10-六溴环十二烷（HBCD）测定结果的质量和可比性，组织了两项实验室间比对研究。多达13个实验室测定了鱼肝油、鲱鱼片、鲑鱼片、黄油和鸡肉中HBCD的总浓度，或α-、β-和γ-HBCD的浓度，或两者皆测。各实验室能够以令人满意的质量（相对标准偏差<35%）测定海洋样品中HBCD的总浓度。然而，对HBCD污染较低（<约2 ng g⁻¹脂质重量）的样品的分析仍需改进。液相色谱-质谱联用（LC-MS）和气相色谱-质谱联用（GC-MS）测得的HBCD总浓度之间未发现统计学上的显著差异。据我们所知，这是关于生物样品中HBCD测定的实验室间比对研究的首份报告，其中包含足够数量参与者的结果以进行统计评估。
