日本女性母乳中六溴环十二烷的时间趋势。
Time trend of hexabromocyclododecane in the breast milk of Japanese women.
作者信息
Kakimoto Kensaku, Akutsu Kazuhiko, Konishi Yoshimasa, Tanaka Yukio
机构信息
Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
出版信息
Chemosphere. 2008 Apr;71(6):1110-4. doi: 10.1016/j.chemosphere.2007.10.035. Epub 2008 Feb 20.
Hexabromocyclododecane (HBCD) is a type of brominated flame retardant. We investigated the time trend of the stereoisomer-specific concentrations of HBCD (alpha, beta, and gamma) in breast milk samples of Japanese women by using liquid chromatography-tandem mass spectrometry (LC/MS/MS). The pooled milk lipid samples collected in 1973, 1978, 1983, 1988, 1993, 1999, and from 2000 to 2006 were analysed. The concentration was below the detection limit in the samples collected between 1973 and 1983 and increased in those collected since 1988. Between 1988 and 2006, alpha-HBCD was detected in all 11 breast milk samples collected from 25 to 29-year-old Japanese women; gamma-HBCD, in 7; and beta-HBCD, in none of the samples. Time trend of summation operatorHBCD appeared to be related to that of the industrial HBCD consumption level in Japan.
六溴环十二烷（HBCD）是一种溴化阻燃剂。我们使用液相色谱 - 串联质谱法（LC/MS/MS）研究了日本女性母乳样本中HBCD（α、β和γ）立体异构体特异性浓度的时间趋势。分析了1973年、1978年、1983年、1988年、1993年、1999年以及2000年至2006年收集的混合乳脂样本。1973年至1983年期间收集的样本中浓度低于检测限，1988年以后收集的样本中浓度有所增加。在1988年至2006年期间，从25至29岁日本女性收集的所有11份母乳样本中均检测到α - HBCD；7份样本中检测到γ - HBCD；所有样本中均未检测到β - HBCD。ΣHBCD的时间趋势似乎与日本工业HBCD消费水平的时间趋势相关。
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