Mazzini Guilherme S, Schaf Débora V, Vinadé Elsa R, Horowitz Estela, Bruch Ricardo S, Brunm Liz M B P, Gonçalves Carlos A, Bacal Fernando, Souza Diogo O, Portela Luis V C, Bordignon Solange
Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil.
J Card Fail. 2007 Dec;13(10):850-4. doi: 10.1016/j.cardfail.2007.07.009.
The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease.
We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426-3591]) were higher than in controls (35 pg/mL [29-55]), P < .001. S100B serum levels were higher in patients group (0.051 microg/L [0.022-0.144]) than in controls (0.017 microg/L [0.003-0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013).
Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.
S100B蛋白被认为是脑损伤的生化标志物。然而，我们的研究小组发现，分离的大鼠心脏会释放S100B。在本研究中，我们调查了扩张型心肌病（DCM）患者血清中S100B的水平，以评估其在心脏病中的水平。
我们选择了DCM患者，排除了任何可能影响S100B血清水平的情况。对照组在性别和年龄上进行了匹配。两组均接受了临床评估和超声心动图检查。我们测量了S100B和NT-proBNP的血清水平（以中位数[四分位间距]表示）。患者组的NT-proBNP水平（1462 pg/mL [426 - 3591]）高于对照组（35 pg/mL [29 - 55]），P <.001。患者组的S100B血清水平（0.051 μg/L [0.022 - 0.144]）高于对照组（0.017 μg/L [0.003 - 0.036]），P =.009。此外，我们仅在患者组中发现S100B与NT-proBNP血清水平呈正相关（Spearman系数r = 0.534；P =.013）。
尽管我们不能排除来自脑的S100B的影响，但DCM患者中S100B与NT-proBNP水平的正相关表明心肌是S100B血清水平升高的主要来源。
