Department of Internal Medicine I, University Hospital Würzburg, 97080 Würzburg, Germany.
German Comprehensive Heart Failure Center, University Hospital Würzburg, 97087 Würzburg, Germany.
Int J Mol Sci. 2024 Aug 22;25(16):9094. doi: 10.3390/ijms25169094.
S100 calcium-binding protein B (S100B) is a protein primarily known as a biomarker for central nervous system (CNS) injuries, reflecting blood-brain barrier (BBB) permeability and dysfunction. Recently, S100B has also been implicated in cardiovascular diseases, including heart failure (HF). Thus, we investigated serum levels of S100B in 146 chronic HF patients from the Cognition.Matters-HF study and their association with cardiac and cognitive dysfunction. The median S100B level was 33 pg/mL (IQR: 22-47 pg/mL). Higher S100B levels were linked to longer HF duration ( = 0.014) and increased left atrial volume index ( = 0.041), but also with a higher prevalence of mild cognitive impairment ( = 0.023) and lower visual/verbal memory scores ( = 0.006). In a multivariable model, NT-proBNP levels independently predicted S100B (T-value = 2.27, = 0.026). S100B did not impact mortality (univariable HR (95% CI) 1.00 (0.99-1.01); = 0.517; multivariable HR (95% CI) 1.01 (1.00-1.03); = 0.142), likely due to its reflection of acute injury rather than long-term outcomes and the mild HF phenotype in our cohort. These findings underscore S100B's value in comprehensive disease assessment, reflecting both cardiac dysfunction and potentially related BBB disruption.
S100 钙结合蛋白 B（S100B）是一种主要作为中枢神经系统（CNS）损伤标志物的蛋白质，反映血脑屏障（BBB）的通透性和功能障碍。最近，S100B 也与心血管疾病有关，包括心力衰竭（HF）。因此，我们研究了认知障碍 - HF 研究中的 146 名慢性 HF 患者的血清 S100B 水平及其与心脏和认知功能障碍的关系。S100B 的中位数水平为 33pg/mL（IQR：22-47pg/mL）。较高的 S100B 水平与 HF 持续时间较长（ = 0.014）和左心房容积指数增加（ = 0.041）相关，但也与轻度认知障碍的患病率较高（ = 0.023）和视觉/语言记忆评分较低（ = 0.006）相关。在多变量模型中，NT-proBNP 水平独立预测 S100B（T 值= 2.27， = 0.026）。S100B 对死亡率没有影响（单变量 HR（95%CI）1.00（0.99-1.01）； = 0.517；多变量 HR（95%CI）1.01（1.00-1.03）； = 0.142），可能是因为它反映的是急性损伤，而不是长期结果，并且我们队列中的 HF 表型较轻。这些发现强调了 S100B 在全面疾病评估中的价值，反映了心脏功能障碍和潜在相关的 BBB 破坏。
