Laboratoire Matériaux et Ingénierie Mécanique (MATIM), UFR de Sciences Exactes et Naturelles, Université de Reims Champagne-Ardenne, 51687 Reims, France.
Biomatériaux et Inflammation en site Osseux (EA 4691 BIOS), SFR CAP-Santé, UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51095 Reims, France.
Molecules. 2023 Jan 18;28(3):981. doi: 10.3390/molecules28030981.
This work studies two copper-based alloys as potential antimicrobial weapons for sectors where surface hygiene is essential. Effects of different alloying elements addition at the same Cu content (92.5% by weight) on the corrosion resistance and the antibacterial performance of two copper alloys were studied in an aerated disinfectant solution (0.25% Aniosurf Premium (D)) by electrochemical corrosion, X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and antibacterial tests. Results showed that the nature of the alloying elements had a clear influence on the corrosion resistance and antibacterial performance. Electrochemical impedance results and surface analyses demonstrate the presence of organic compounds bound on the substrate and that a film covers part of the total active surface and may act as a protective barrier by preventing the interaction between metal and solution, decreasing the antimicrobial performance of copper-based materials. Low zinc and silicon contents in copper alloys allows for better aging behavior in D solution while maintaining good antibacterial performance. The XPS and ToF-SIMS results indicated that artificial aging in disinfectant enhanced Cu enrichment in the organic film formed, which could effectively stimulate the release of Cu ions from the surface.
本工作研究了两种铜基合金，它们可能是表面卫生至关重要的领域的潜在抗菌武器。通过电化学腐蚀、X 射线光电子能谱 (XPS)、飞行时间二次离子质谱 (ToF-SIMS) 和抗菌试验，研究了在充气消毒剂溶液（0.25% Aniosurf Premium (D)）中，相同 Cu 含量（92.5% 重量）下不同合金元素添加对两种铜合金的耐腐蚀性和抗菌性能的影响。结果表明，合金元素的性质对耐腐蚀性和抗菌性能有明显影响。电化学阻抗结果和表面分析表明，有机化合物结合在基底上，部分总活性表面被一层膜覆盖，这层膜可能通过防止金属与溶液的相互作用形成一个保护性屏障，从而降低铜基材料的抗菌性能。铜合金中锌和硅含量低，有利于在 D 溶液中更好的时效行为，同时保持良好的抗菌性能。XPS 和 ToF-SIMS 结果表明，消毒剂中的人工时效增强了有机膜中 Cu 的富集，从而有效刺激了 Cu 离子从表面的释放。
