Haleng J, Pincemail J, Defraigne J O, Charlier C, Chapelle J P
Service de Chimie Médicale, CHU Sart Tilman, Liège, Belgique.
Rev Med Liege. 2007 Oct;62(10):628-38.
Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) and the antioxidant network, in favour of the former. Our lifestyle (smoking, alcoholism, obesity, intense physical exercise), but also our inadequate diet, contributes to significantly increase the production of ROS in our organism. This is potentially associated with an increased risk of developing ageing-related pathologies such as cardiovascular diseases and cancer. As a matter of prevention, it is necessary to have in hands a high technology allowing to correctly evidence the oxidative stress status of an individual in order to render optimal our antioxidant defences and to decrease the oxidative damages in DNA, proteins and lipids.
氧化应激被定义为活性氧(ROS)产生与抗氧化网络之间的失衡,且前者占优势。我们的生活方式(吸烟、酗酒、肥胖、剧烈体育锻炼),还有我们不合理的饮食,都会导致机体中ROS的产生显著增加。这可能会增加患与衰老相关疾病(如心血管疾病和癌症)的风险。作为一种预防措施,有必要掌握一项高科技手段,以便正确地证明个体的氧化应激状态,从而优化我们的抗氧化防御能力,并减少DNA、蛋白质和脂质中的氧化损伤。