使用离子液体负载糖基化合成低聚甘露聚糖
Oligomannan synthesis using ionic liquid supported glycosylation.
作者信息
Pathak Ashish K, Yerneni Charu K, Young Zac, Pathak Vibha
机构信息
Department of Chemistry, Western Illinois University, Macomb, Illinois 61455, USA.
出版信息
Org Lett. 2008 Jan 3;10(1):145-8. doi: 10.1021/ol702743x. Epub 2007 Dec 11.
Abstract
The synthesis of complex oligosaccharides has been a challenge for researchers. Herein, we describe a strategy for the synthesis of an activated oligomannan 1 that employs ionic liquid (IL) support glycosylation methodology on an IL-tagged mannosyl fluoride donor. This method is capable of rapidly producing linear alpha(1-->6) oligomannan thioglycosides in a convenient and cost-effective manner without the need of column purification after each glycosylation step.
摘要
复杂寡糖的合成一直是研究人员面临的挑战。在此，我们描述了一种合成活化寡聚甘露糖1的策略，该策略在带有离子液体（IL）标签的氟代甘露糖供体上采用离子液体（IL）支持的糖基化方法。该方法能够以方便且经济高效的方式快速生成线性α(1→6)寡聚甘露糖硫苷，且无需在每个糖基化步骤后进行柱纯化。
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Solid-Phase Capture-Release Strategy Applied to Oligosaccharide Synthesis on a Soluble Polymer Support This work was supported in part by the Mizutani Foundation for Glycoscience (grant to Y.I.), the RIKEN Presidential Fund (grant to S.M.), and the Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research to S.M.). We thank Dr. Teiji Chihara and his staff for the elemental analyses, Ms. Yasuko Tanaka for her contribution at the exploratory stage of this work, and Ms. Akemi Takahashi for her technical assistance.应用于可溶性聚合物载体上寡糖合成的固相捕获-释放策略 本研究部分得到了水谷糖科学基金会（授予Y.I.的资助）、理化学研究所总裁基金（授予S.M.的资助）以及文部科学省（授予S.M.的科研资助金）的支持。我们感谢Teiji Chihara博士及其工作人员进行元素分析，感谢Tanaka Yasuko女士在本研究探索阶段所做的贡献，以及Takahashi Akemi女士提供的技术协助。
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