Svický E, Skarda R, Marcaník J, Hrusovský J
Vysoká skola veterinárska, Kosice.
Vet Med (Praha). 1991 Oct;36(10):619-23.
Sixty-one sheep were administered experimentally a VX chemical (organophosphate) at different rates. In the process of dissection, samples were taken for a histopathological examination. These were samples of brain, liver, kidneys, rumen wall, small intestine, muscles, myocardium, lungs and spleen. For another histochemical examination, samples of tongue, m. longissimus dorsi, jejunum, rumen, liver, kidneys and m. interconstalis were also taken. The activities of alkaline and acid phosphatase, nonspecific esterase, acetylcholinesterase and dehydrogenase of lactic acid were investigated. The most significant changes were found out in the lungs - in form of oedemas and acute catarrhal bronchopneumonias in those animals which died within three days after chemical administration. Sporadic haemorrhages or haemorrhages in form of vast spots were found out under the epicardium. Their range did not relate to the amount of the chemical administered. Rather dilated vessels were observed in the brain and also in the meninges. The histochemical examination showed different activities of enzymes in particular organs of sheep.
给61只绵羊以不同剂量进行VX化学物质（有机磷酸酯）的实验性给药。在解剖过程中，采集样本进行组织病理学检查。这些样本包括脑、肝、肾、瘤胃壁、小肠、肌肉、心肌、肺和脾。为了进行另一项组织化学检查，还采集了舌、背最长肌、空肠、瘤胃、肝、肾和肋间肌的样本。研究了碱性磷酸酶、酸性磷酸酶、非特异性酯酶、乙酰胆碱酯酶和乳酸脱氢酶的活性。在那些化学物质给药后三天内死亡的动物的肺中发现了最显著的变化——表现为水肿和急性卡他性支气管肺炎。在心外膜下发现了散在出血或大片状出血。其范围与所给化学物质的量无关。在脑和脑膜中观察到血管扩张。组织化学检查显示绵羊特定器官中酶的活性不同。
