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本文引用的文献

1
The association of MRI findings and neuropsychological functioning after the first recognized seizure.首次确诊癫痫发作后MRI表现与神经心理功能的关联。
Epilepsia. 2007 Jun;48(6):1067-74. doi: 10.1111/j.1528-1167.2007.01088.x. Epub 2007 Apr 18.
2
The development of intellectual abilities in pediatric temporal lobe epilepsy.小儿颞叶癫痫患者智力能力的发展
Epilepsia. 2007 Jan;48(1):201-4. doi: 10.1111/j.1528-1167.2006.00904.x.
3
Seizures and antiepileptic drugs: does exposure alter normal brain development?癫痫发作与抗癫痫药物:药物暴露会改变正常脑发育吗?
Epilepsia. 2006 Dec;47(12):1999-2010. doi: 10.1111/j.1528-1167.2006.00894.x.
4
Global and local development of gray and white matter volume in normal children and adolescents.正常儿童和青少年脑灰质和白质体积的整体及局部发育情况
Exp Brain Res. 2007 Apr;178(3):296-307. doi: 10.1007/s00221-006-0732-z. Epub 2006 Oct 19.
5
Antisocial and seizure susceptibility phenotypes in an animal model of epilepsy are normalized by impairment of brain corticotropin-releasing factor.在癫痫动物模型中,通过损伤脑促肾上腺皮质激素释放因子可使反社会行为和癫痫发作易感性表型恢复正常。
Epilepsy Behav. 2007 Feb;10(1):8-15. doi: 10.1016/j.yebeh.2006.08.013. Epub 2006 Oct 4.
6
Children with new-onset epilepsy: neuropsychological status and brain structure.新发癫痫患儿:神经心理状态与脑结构
Brain. 2006 Oct;129(Pt 10):2609-19. doi: 10.1093/brain/awl196. Epub 2006 Aug 23.
7
Models of pediatric epilepsies: strategies and opportunities.小儿癫痫模型:策略与机遇
Epilepsia. 2006 Aug;47(8):1407-14. doi: 10.1111/j.1528-1167.2006.00674_1.x.
8
Brain development in children and adolescents: insights from anatomical magnetic resonance imaging.儿童和青少年的脑发育:来自解剖磁共振成像的见解
Neurosci Biobehav Rev. 2006;30(6):718-29. doi: 10.1016/j.neubiorev.2006.06.001. Epub 2006 Aug 2.
9
The consequences of idiopathic partial epilepsies in relation to neuropsychological functioning: a closer look at the associated mathematical disability.特发性部分性癫痫对神经心理功能的影响:深入探讨相关的数学障碍
Epileptic Disord. 2006 Mar;8(1):24-31.
10
Open-field behaviors and water-maze learning in the F substrain of Ihara epileptic rats.伊原癫痫大鼠F亚系的旷场行为和水迷宫学习
Epilepsia. 2006 Jan;47(1):55-63. doi: 10.1111/j.1528-1167.2006.00370.x.

新发小儿癫痫的认知及磁共振容积异常

Cognitive and magnetic resonance volumetric abnormalities in new-onset pediatric epilepsy.

作者信息

Hermann Bruce P, Jones Jana, Sheth Raj, Seidenberg Michael

机构信息

Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison 53792, USA.

出版信息

Semin Pediatr Neurol. 2007 Dec;14(4):173-80. doi: 10.1016/j.spen.2007.08.003.

DOI:10.1016/j.spen.2007.08.003
PMID:18070673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2695488/
Abstract

This paper addresses the issue of cognitive morbidity and abnormalities in quantitative MR volumetric in children with new and recent onset idiopathic epilepsy. The available literature suggests that mild diffuse cognitive problems are evident in children with new onset epilepsy in the context of intact whole brain and lobar volumetrics. Subsets of children can be identified with salient academic and volumetric abnormalities. These findings represent the baseline upon which any subsequent effects of chronic epilepsy may accrue.

摘要

本文探讨了新发和近期发作的特发性癫痫患儿的认知发病率问题以及定量磁共振体积测量中的异常情况。现有文献表明,在全脑和脑叶体积测量正常的情况下,新发癫痫患儿存在明显的轻度弥漫性认知问题。可以识别出一部分在学业和体积测量方面有显著异常的儿童。这些发现代表了慢性癫痫后续可能产生任何影响的基线。