García Díez F, Fernández Natal I, Guerreiro González R, González del Valle C
Servicio de Urología II, Complejo Hospitalario de León, España.
Arch Esp Urol. 1991 Nov;44(9):1069-72.
Corynebacterium D2, a saprophytic microorganism of skin, causes alkaline encrusted cystitis in patients with a previous bladder injury. In 5 patients that had presented this nosological entity, these gram-positive rods were isolated in urine cultures and calculi. Four patients had undergone urological instrumentation maneuvers and one patient (female) had a history of recurrent cystitis from gram-negative bacteria. Corynebacterium D2 grows slowly and under certain conditions, as those described above, must be considered pathological despite counts of less than 100,000/ufc-cc. It is ureolytic and highly resistant to antibiotics. The synergistic effects of antimicrobials, acetohydroxamic acid and transurethral resection of the lithiasic plaques achieve satisfactory treatment of alkaline encrusted cystitis from Corynebacterium D2.
棒状杆菌D2是一种皮肤腐生微生物，可导致既往有膀胱损伤的患者发生碱性结痂性膀胱炎。在5例出现这种疾病实体的患者中，这些革兰氏阳性杆菌在尿培养物和结石中被分离出来。4例患者接受了泌尿外科器械操作，1例女性患者有革兰氏阴性菌引起的复发性膀胱炎病史。棒状杆菌D2生长缓慢，在上述某些条件下，尽管计数低于100,000/ufc-cc，也必须被视为病理性的。它具有尿素分解能力，且对抗生素高度耐药。抗菌药物、乙酰氧肟酸和经尿道切除结石斑块的协同作用对棒状杆菌D2引起的碱性结痂性膀胱炎取得了满意的治疗效果。
