Soriano F, Ponte C, Santamaria M, Aguado J M, Wilhelmi I, Vela R, Delatte L C
J Clin Microbiol. 1985 May;21(5):788-92. doi: 10.1128/jcm.21.5.788-792.1985.
In four patients with alkaline-encrusted cystitis, Corynebacterium group D2 was isolated from consecutive urine cultures and stones. Encrusted cystitis occurred in bladders harboring inflammatory or tumorous lesions in patients with chronic or recurrent urinary tract infections appearing after surgery or instrumentation. The urease activity of Corynebacterium group D2 and the neutralization of this enzyme by acetohydroxamic acid are shown. Clinical improvement, disappearance of struvite crystals, and decrease of the urine pH were obtained when these bacteria were eliminated from urine samples. Corynebacterium group D2 strains were highly resistant to many antimicrobial agents but were highly susceptible to norfloxacin and vancomycin when tested at two pHs (7.4 and 8.5).
在4例碱性结痂性膀胱炎患者中，连续的尿液培养及结石样本中分离出了D2群棒状杆菌。结痂性膀胱炎发生于慢性或复发性尿路感染患者的膀胱，这些患者在手术或器械操作后出现炎症或肿瘤性病变。研究展示了D2群棒状杆菌的脲酶活性以及乙酰氧肟酸对该酶的中和作用。当从尿液样本中清除这些细菌后，患者临床症状改善，鸟粪石晶体消失，尿液pH值下降。D2群棒状杆菌菌株对许多抗菌药物具有高度耐药性，但在两种pH值（7.4和8.5）下进行测试时，对诺氟沙星和万古霉素高度敏感。
