Ohuchi Hiroko
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Med Phys. 2007 Nov;34(11):4207-12. doi: 10.1118/1.2795828.
A novel method that can greatly improve the dosimetric sensitivity limit of a radiochromic film (RCF) through use of a set of color components, e.g., red and green, outputs from a RGB color scanner has been developed. RCFs are known to have microscopic and macroscopic nonuniformities, which come from the thickness variations in the film's active radiochromic layer and coating. These variations in the response make the optical signal-to-noise ratio lower, resulting in lower film sensitivity. To mitigate the effects of RCF nonuniform response, an optical common-mode rejection (CMR) was developed. The CMR compensates nonuniform response by creating a ratio of the two signals where the factors common to both numerator and denominator cancel out. The CMR scheme was applied to the mathematical operation of creating a ratio using two components, red and green outputs from a scanner. The two light component lights are neighboring wavebands about 100 nm apart and suffer a common fate, with the exception of wavelength-dependent events, having passed together along common attenuation paths. Two types of dose-response curves as a function of delivered dose ranging from 3.7 mGy to 8.1 Gy for 100 kV x-ray beams were obtained with the optical CMR scheme and the conventional analysis method using red component, respectively. In the range of 3.7 mGy to 81 mGy, the optical densities obtained with the optical CMR showed a good consistency among eight measured samples and an improved consistency with a linear fit within 1 standard deviation of each measured optical densities, while those with the conventional analysis exhibited a large discrepancy among eight samples and did not show a consistency with a linear fit.
已经开发出一种新方法,该方法可通过使用一组颜色分量(例如红色和绿色)来大大提高放射变色薄膜(RCF)的剂量测定灵敏度极限,这些颜色分量是RGB颜色扫描仪的输出。已知RCF存在微观和宏观不均匀性,这源于薄膜活性放射变色层和涂层的厚度变化。这些响应变化会使光信噪比降低,从而导致薄膜灵敏度降低。为了减轻RCF不均匀响应的影响,开发了一种光学共模抑制(CMR)方法。CMR通过创建两个信号的比率来补偿不均匀响应,在该比率中,分子和分母共有的因素相互抵消。CMR方案应用于使用扫描仪的红色和绿色两个分量创建比率的数学运算。这两个光分量光的波长相差约100 nm,是相邻波段,除了与波长相关的事件外,它们沿着共同的衰减路径一起传播,命运相同。分别使用光学CMR方案和使用红色分量的传统分析方法,获得了100 kV X射线束在3.7 mGy至8.1 Gy范围内随剂量变化的两种剂量响应曲线。在3.7 mGy至81 mGy范围内,光学CMR获得的光密度在八个测量样品之间显示出良好的一致性,并且在每个测量光密度的1个标准差内与线性拟合的一致性得到改善,而传统分析方法获得的光密度在八个样品之间存在很大差异,并且与线性拟合不一致。