单一化学物质-DNA加合物的生物学特性：二十年的展望。
Biological properties of single chemical-DNA adducts: a twenty year perspective.
作者信息
Delaney James C, Essigmann John M
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, USA.
出版信息
Chem Res Toxicol. 2008 Jan;21(1):232-52. doi: 10.1021/tx700292a. Epub 2007 Dec 12.
Abstract
The genome and its nucleotide precursor pool are under sustained attack by radiation, reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and certain drugs. As a result, a large and heterogeneous population of damaged nucleotides forms in all cells. Some of the lesions are repaired, but for those that remain, there can be serious biological consequences. For example, lesions that form in DNA can lead to altered gene expression, mutation, and death. This perspective examines systems developed over the past 20 years to study the biological properties of single DNA lesions.
摘要
基因组及其核苷酸前体池持续受到辐射、活性氧和氮物种、化学致癌物、水解反应及某些药物的攻击。因此，所有细胞中都会形成大量且异质的受损核苷酸群体。一些损伤会被修复，但对于那些残留的损伤，可能会产生严重的生物学后果。例如，DNA中形成的损伤可导致基因表达改变、突变和细胞死亡。本文探讨了过去20年中为研究单个DNA损伤的生物学特性而开发的系统。
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