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英国针具交换项目中引入柠檬酸盐的影响:英国柴郡和默西塞德的回顾性队列研究。

The impact of citrate introduction at UK syringe exchange programmes: a retrospective cohort study in Cheshire and Merseyside, UK.

机构信息

Centre for Public Health, Faculty of Health and Applied Social Sciences, Liverpool John Moores University, Castle House, North Street, Liverpool, L3 2AY, UK.

出版信息

Harm Reduct J. 2007 Dec 11;4:21. doi: 10.1186/1477-7517-4-21.

Abstract

BACKGROUND

In 2003, it became legal in the UK for syringe exchange programmes (SEPs) to provide citrate to injecting drug users to solubilise heroin. Little work has been undertaken on the effect of policy change on SEP function. Here, we examine whether the introduction of citrate in Cheshire and Merseyside SEPs has altered the number of heroin/crack injectors accessing SEPs, the frequency at which heroin/crack injectors visited SEPs and the number of syringes dispensed.

METHODS

Eleven SEPs in Cheshire and Merseyside commenced citrate provision in 2003. SEP-specific data for the six months before and six months after citrate was introduced were extracted from routine monitoring systems relating to heroin and crack injectors. Analyses compared all individuals attending pre and post citrate and matched analyses only those individuals attending in both periods (defined as 'longitudinal attenders'). Non-parametric tests were used throughout.

RESULTS

Neither new (first seen in either six months period) nor established clients visited SEPs more frequently post citrate. New clients collected significantly less syringes per visit post citrate, than pre citrate (14.5,10.0; z = 1.992, P < 0.05). Matched pair analysis showed that the median number of visits for 'longitudinal attenders' (i.e. those who attended in both pre and post citrate periods) increased from four pre citrate to five post citrate (z = 2.187, P < 0.05) but the number of syringes collected remained unchanged. These changes were not due to seasonal variation or other changes in service configuration.

CONCLUSION

The introduction of citrate did not negatively affect SEP attendance. 'Longitudinal attenders' visited SEPs more frequently post citrate, providing staff with greater opportunity for intervention and referral. As the number of syringes they collected each visit remained unchanged the total number of clean syringes made available to this group of injectors increased very slightly between the pre and post citrate periods. However, new clients collected significantly less syringes post citrate than pre citrate, possibly due to staff concerns regarding the amount of citrate (and thus syringes) to dispense safely to new clients. These concerns should not be allowed to negatively impact on the number of syringes dispensed.

摘要

背景

2003 年,英国允许注射毒品者通过注射器交换计划(SEPs)获取柠檬酸盐来溶解海洛因。在此之后,几乎没有开展任何工作来评估政策变化对 SEP 功能的影响。在此,我们研究了在柴郡和默西塞德郡 SEP 中引入柠檬酸盐是否改变了海洛因/快克吸食者使用 SEP 的数量、使用频率以及分发的注射器数量。

方法

2003 年,柴郡和默西塞德郡的 11 个 SEP 开始提供柠檬酸盐。从与海洛因和快克吸食者有关的常规监测系统中提取了 SEP 特定的六个月前和六个月后数据。分析比较了所有在前和后柠檬酸盐时期就诊的个体,并仅对那些在两个时期都就诊的个体进行了匹配分析(定义为“纵向就诊者”)。整个过程中使用了非参数检验。

结果

新(在任何六个月期间首次就诊)和老(已经就诊)客户在柠檬酸盐后都没有更频繁地访问 SEP。新客户每次就诊收集的注射器数量明显少于柠檬酸盐前(14.5,10.0;z = 1.992,P < 0.05)。匹配对分析显示,“纵向就诊者”(即那些在柠檬酸盐前和后两个时期都就诊的人)的中位数就诊次数从四次增加到五次(z = 2.187,P < 0.05),但收集的注射器数量保持不变。这些变化不是由于季节性变化或服务配置的其他变化引起的。

结论

引入柠檬酸盐并未对 SEP 就诊产生负面影响。“纵向就诊者”在柠檬酸盐后更频繁地访问 SEP,为工作人员提供了更多的干预和转介机会。由于他们每次就诊收集的注射器数量保持不变,因此在柠檬酸盐前和后两个时期,这组注射者可用的清洁注射器总数略有增加。然而,新客户在柠檬酸盐后收集的注射器数量明显少于柠檬酸盐前,这可能是由于工作人员担心向新客户安全分发的柠檬酸盐(因此注射器)的数量。不应让这些担忧对分发的注射器数量产生负面影响。

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