Högdahl M, Kihlström E
Department of Clinical Microbiology, University Hospital, Linköping University, Linköping S-581 85, Sweden.
Int J STD AIDS. 2007 Dec;18(12):835-8. doi: 10.1258/095646207782716983.
Leucocyte esterase (LE) in first-voided urine (FVU) and presence of leucocytes in urethral and cervical smears were evaluated to identify Mycoplasma genitalium infection in 416 men and 417 women attending Department of Genitourinary Medicine. M. genitalium was diagnosed in FVU specimens by realtime polymerase chain reaction. The prevalence of M. genitalium was 6.5% in women and 6.7% in men. In total, 88.5% (23/26) of M. genitalium-infected men were identified by a combination of urethral smear and the LE test. In women, the combination of urethral and/or cervical smears and/or a positive LE test identified 91.3% (21/23) of M. genitalium-infected patients. Organism load in FVU correlated significantly with presence of urethritis (> or =4 leucocytes per high-power field) in men. A combination of LE testing of urine and urethral and/or cervical smears can be used as screening tests to select patients for specific M. genitalium testing. By this strategy, about 10% of infected individuals will remain undetected.
对416名男性和417名前往泌尿生殖医学科就诊的女性，检测了首次晨尿（FVU）中的白细胞酯酶（LE）以及尿道和宫颈涂片中的白细胞，以确定生殖支原体感染情况。通过实时聚合酶链反应诊断FVU标本中的生殖支原体。生殖支原体的患病率在女性中为6.5%，在男性中为6.7%。总体而言，88.5%（23/26）的生殖支原体感染男性通过尿道涂片和LE检测联合得以确诊。在女性中，尿道和/或宫颈涂片和/或LE检测阳性联合可确诊91.3%（21/23）的生殖支原体感染患者。男性FVU中的病原体载量与尿道炎（每高倍视野≥4个白细胞）的存在显著相关。尿液LE检测与尿道和/或宫颈涂片联合可作为筛选试验，以选择患者进行特定的生殖支原体检测。通过这种策略，约10%的感染个体将仍未被检测到。
