Guldner N W, Tilmans M H, DeHaan H, Ruck K, Bressers H, Messmer B J
Department of Thoracic and Cardiovascular Surgery, RWTH Aachen, West Germany.
J Card Surg. 1991 Mar;6(1 Suppl):175-83. doi: 10.1111/jocs.1991.6.1s.175.
One-layered skeletal muscle ventricles (SMV) were constructed from latissimus dorsi (LD) muscles extrathoracally in six calves and trained under electrical stimulation on totally implanted mock circulation systems. These ventricles had low preloads of about 5 mmHg. The results showed that training against a resistance similar to the human aorta does not create an effective blood pump. But conditioning against a highly complaint workload makes them six times more effective. Therefore, further research on this observation is mandatory. After a conditioning of 16 to 63 days, all implanted mock circulations became infected due to perforated skin, so these experiments had to be terminated. To avoid these infections, we developed and tested an intrathoracic implantable mock circulation system with a highly compliant workload. With a double-layered muscle pump, systolic pressure 120-140 mmHg was generated and an output of more than 31/min was obtained. SMVs with a low end-diastolic pressure seem to be suitable for construction of an effective blood pump between the left atrium and the aorta as a left heart assist device.
在六头小牛的胸外，利用背阔肌构建了单层骨骼肌心室（SMV），并在完全植入式模拟循环系统上进行电刺激训练。这些心室的预负荷较低，约为5 mmHg。结果表明，针对与人主动脉相似的阻力进行训练并不能产生有效的血泵。但针对高度顺应性的工作负荷进行调节会使其效率提高六倍。因此，必须对这一观察结果进行进一步研究。在经过16至63天的调节后，由于皮肤穿孔，所有植入的模拟循环都发生了感染，因此这些实验不得不终止。为避免这些感染，我们开发并测试了一种具有高度顺应性工作负荷的胸腔内植入式模拟循环系统。通过双层肌肉泵，可产生120 - 140 mmHg的收缩压，并获得超过31/min的输出量。舒张末期压力较低的SMV似乎适合作为左心辅助装置，在左心房和主动脉之间构建有效的血泵。
