Debrah Alexander Yaw, Mand Sabine, Marfo-Debrekyei Yeboah, Batsa Linda, Pfarr Kenneth, Buttner Marcelle, Adjei Ohene, Buttner Dietrich, Hoerauf Achim
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany.
Trop Med Int Health. 2007 Dec;12(12):1433-41. doi: 10.1111/j.1365-3156.2007.01949.x.
To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti.
In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 mug/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS).
Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6-week regimen. Circulating filarial antigenaemia and FDS were strongly correlated.
A 4-week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics.
评估多西环素作为抗班氏吴策线虫的杀成虫剂的疗效。
在加纳西部地区，招募了18名感染班氏吴策线虫的患者，每天给予200毫克多西环素治疗，持续4周。7名未治疗的患者作为对照。多西环素治疗4个月后，所有患者接受150微克/千克伊维菌素治疗。对患者进行沃尔巴克氏体和微丝蚴载量、抗原血症及丝虫舞症（FDS）监测。
多西环素治疗4个月后，病例组的沃尔巴克氏体载量显著低于对照组；治疗24个月后，病例组的微丝蚴血症、抗原血症及FDS发生率显著低于对照组。最重要的是，4周的多西环素治疗可杀死80%的成虫，这与6周治疗方案的结果相当。循环丝虫抗原血症与FDS密切相关。
4周的多西环素治疗方案似乎足以杀死成年班氏吴策线虫，对个体患者的治疗可能具有优势，例如在门诊治疗中。
