大麻使用、滥用和依赖与惊恐发作及惊恐障碍之间的前瞻性关联。
Prospective associations between cannabis use, abuse, and dependence and panic attacks and disorder.
作者信息
Zvolensky Michael J, Lewinsohn Peter, Bernstein Amit, Schmidt Norman B, Buckner Julia D, Seeley John, Bonn-Miller Marcel O
机构信息
University of Vermont, Department of Psychology, Burlington, VT 05405-0134, USA.
出版信息
J Psychiatr Res. 2008 Oct;42(12):1017-23. doi: 10.1016/j.jpsychires.2007.10.012. Epub 2008 Feb 20.
Abstract
The present study prospectively evaluated cannabis use, abuse, and dependence in relation to the development of panic attacks and panic disorder. Participants at the start of the study were adolescents (n=1709) with a mean age of 16.6 years (SD=1.2; time 1) and were re-assessed 1 year later (time 2) and then again as young adults (time 3; mean age=24.2 years, SD=0.6). Results indicated that cannabis use and dependence were significantly prospectively associated with an increased odds for the development of panic attacks and panic disorder. However, cannabis was not incrementally associated with the development of panic after controlling for daily cigarette smoking. The theoretical and clinical implications of these findings are discussed.
摘要
本研究前瞻性地评估了大麻使用、滥用及依赖与惊恐发作和惊恐障碍发生之间的关系。研究开始时的参与者为青少年（n = 1709），平均年龄16.6岁（标准差 = 1.2；时间1），1年后（时间2）再次进行评估，随后在青年期（时间3；平均年龄 = 24.2岁，标准差 = 0.6）又进行了评估。结果表明，大麻使用和依赖与惊恐发作和惊恐障碍发生几率的增加显著相关。然而，在控制每日吸烟因素后，大麻与惊恐发作的发生并无增量关联。本文讨论了这些研究结果的理论和临床意义。
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