Eljarrat Ethel, Guerra Paula, Martínez Elena, Farré Marinella, Alvarez Juan G, López-Teijón Marisa, Barceló Damia
Department of Environmental Chemistry, IDAEA, Consejo Superior de Investigaciones Científicas, Jordi Girona 18-26, 08034 Barcelona, Spain.
Environ Sci Technol. 2009 Mar 15;43(6):1940-6. doi: 10.1021/es802919e.
Samples of human breast milk (n=33) from A Coruña (NW of Spain) collected in 2006 and 2007 were analyzed for HBCD diastereoisomers and enantiomers. HBCD was detected in 30 out of 33 human milk samples, at concentration levels ranging between 3 and 188 ng/g lw, with a median value of 27 ng/g lw, showing higher levels than those published for other countries. Diastereoisomeric pattern shows the predominance of the gamma-isomer, with low contribution of the alpha-isomer and the beta-isomer being below the limit of quantification. However, in six samples, there is a dominance of the alpha-isomer versus the gamma-isomer. For the first time, HBCD enantiomeric analysis was carried out in human breast milk samples, showing a selective enantiomeric enrichment in human body. As regards alpha-HBCD, an enrichment of (-)-enantiomer was observed. However, in the case of gamma-HBCD, no clear preference for one or the other enantiomer was found. Finally, and based on the calculated HBCD concentrations in human breast milk from Spain, the daily ingestion rate of HBCD was estimated. The nursing infant dietary intake for HBCD was set at 175 ng (kg of body weight)(-1) day(-1).
对2006年和2007年从西班牙西北部拉科鲁尼亚采集的33份人乳样本进行了六溴环十二烷非对映异构体和对映体分析。在33份人乳样本中的30份中检测到六溴环十二烷，浓度范围在3至188纳克/克脂重之间，中位数为27纳克/克脂重，显示出比其他国家公布的水平更高。非对映体模式显示γ-异构体占主导，α-异构体的贡献较低，β-异构体低于定量限。然而，在六个样本中，α-异构体相对于γ-异构体占主导。首次对人乳样本进行了六溴环十二烷对映体分析，结果显示人体中存在选择性对映体富集。对于α-六溴环十二烷，观察到（-）-对映体的富集。然而，对于γ-六溴环十二烷，未发现对某一种对映体有明显偏好。最后，根据西班牙人乳中计算出的六溴环十二烷浓度，估算了六溴环十二烷的每日摄入量。六溴环十二烷的哺乳婴儿膳食摄入量设定为175纳克/（千克体重）·天。
