Weihkopf Thomas, Blettner Maria, Dantonello Tobias, Jung Irene, Klingebiel Thomas, Koscielniak Ewa, Lückel Monika, Spix Claudia, Kaatsch Peter
German Childhood Cancer Registry (GCCR), Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg University Mainz, Germany.
Eur J Cancer. 2008 Feb;44(3):432-40. doi: 10.1016/j.ejca.2007.11.013.
The incidence of soft tissue sarcoma (STS) in Europe is increasing, but it is unclear whether this increase can also be seen in Germany. We analysed the heterogeneous group of STS recorded to the German Childhood Cancer Registry (GCCR) between 1985 and 2004 with respect to incidence data. Age-specific, age-standardised and cumulative incidence rates were calculated. Additionally, the average annual percent change (AAPC), derived from a Poisson regression model, was estimated, using time in years as the explanatory, continuous variable. Two thousand sixty-one children were diagnosed at a median age of 72 months. Most common are rhabdomyosarcomas (RMS) (n=1202) and fibrosarcomas (n=174). The age-standardised incidence rate (ASR) is 0.9 per 100,000/year for all STS, 0.70 for rhabdomyosarcoma-like (n=1588) and 0.18 for non-rhabdomyosarcoma-like (n=411) STS. AAPC is +0.4% (95%-confidence interval [-0.4;+1.2%]) for STS. In Germany, the increase in incidence rate is less evident than in other European countries.
欧洲软组织肉瘤（STS）的发病率正在上升，但在德国是否也能看到这种上升尚不清楚。我们分析了1985年至2004年间录入德国儿童癌症登记处（GCCR）的异质性STS组的发病率数据。计算了年龄特异性、年龄标准化和累积发病率。此外，使用年份作为解释性连续变量，通过泊松回归模型估计平均年变化百分比（AAPC）。2061名儿童被诊断出患有该病，中位年龄为72个月。最常见的是横纹肌肉瘤（RMS）（n = 1202）和纤维肉瘤（n = 174）。所有STS的年龄标准化发病率（ASR）为每100,000人/年0.9，横纹肌肉瘤样（n = 1588）为0.70，非横纹肌肉瘤样（n = 411）STS为0.18。STS的AAPC为+0.4%（95%置信区间[-0.4；+1.2%]）。在德国，发病率的上升不如其他欧洲国家明显。
