Chi Chia-Yu, Lauderdale Tsai-Ling, Wang Shih-Min, Wu Jing-Ming, Yang Yu-Jen, Liu Ching-Chuan
Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan.
J Clin Microbiol. 2008 Feb;46(2):810-3. doi: 10.1128/JCM.01004-07. Epub 2007 Dec 12.
Infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility (SARV) has been reported worldwide. We report the successful treatment of a pediatric patient with SARV IE and characterization of the infecting strain. The MIC of vancomycin rose from 1.5 to 2 microg/ml, and the SARV was confirmed by population analysis.
耐甲氧西林金黄色葡萄球菌伴万古霉素敏感性降低(SARV)引起的感染性心内膜炎(IE)已在全球范围内有报道。我们报告了1例SARV IE患儿的成功治疗及感染菌株的特征。万古霉素的最低抑菌浓度从1.5微克/毫升升至2微克/毫升,通过群体分析证实为SARV。