2-去甲氧基羰基-2-乙氧基羰基-11-脱氧米索前列醇对四氯化碳诱导的肝炎模型的利胆活性
Choleretic activity of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol on the model of CCl4-induced hepatitis.
作者信息
Sapozhnikova T A, Zarudii F S, Baschenko N Zh, Gabdrahmanova S F, Makara N S, Khisamutdinova R Yu, Ivanova N A, Nazarov V S
机构信息
Laboratory of New Medicinal Agents, Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, Ufa.
出版信息
Bull Exp Biol Med. 2008 Feb;145(2):223-4. doi: 10.1007/s10517-008-0055-0.
PMID:19023974
Abstract
Therapeutic administration of 11-deoxymisoprostol had a hepatoprotective effect, which manifested in a decrease in the content of alanine transaminase and aspartate transaminase in blood plasma, and produced a choleretic effect in rats with CCI4-induced toxic hepatitis.
摘要
11-脱氧米索前列醇的治疗性给药具有肝保护作用，表现为血浆中丙氨酸转氨酶和天冬氨酸转氨酶含量降低，并对四氯化碳诱导的中毒性肝炎大鼠产生利胆作用。
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