绿茶提取物对年轻和老年雄性大鼠学习、记忆、行为及乙酰胆碱酯酶活性的影响。

Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats.

作者信息

Kaur Tranum, Pathak C M, Pandhi P, Khanduja K L

机构信息

Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Brain Cogn. 2008 Jun;67(1):25-30. doi: 10.1016/j.bandc.2007.10.003. Epub 2007 Dec 19.

DOI:10.1016/j.bandc.2007.10.003

PMID:18078701

Abstract

OBJECTIVE

To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats.

METHODS

Young and old rats were orally administered 0.5% green tea extract for a period of eight weeks and were evaluated by passive avoidance, elevated maze plus paradigm and changes in acetylcholinesterase activity.

RESULTS

Treatment of young and old rats with the extract resulted in no significant difference in performance on the rota rod treadmill test/righting reflex time. Green tea extract significantly improved learning and memory in older rats, with increased retention latency to enter difference in passive avoidance test. In the elevated maze test, green tea treatment resulted in significantly more number of entries in the enclosed arm by the young and old rats. Decline in acetylcholinesterase activity was observed in the cerebrum of green tea treated old rats in comparison to the green tea treated young rats.

CONCLUSION

Green tea extract administration is effective in enhancing learning and memory in aged rats, and hence, may serve useful in reversing age-related deficits.

摘要

目的

研究给予绿茶提取物对年轻和老年雄性Wistar大鼠与年龄相关认知的影响。

方法

年轻和老年大鼠口服0.5%绿茶提取物，为期八周，并通过被动回避、高架迷宫加范式以及乙酰胆碱酯酶活性变化进行评估。

结果

用提取物处理年轻和老年大鼠后，在转棒跑步机试验/翻正反射时间上的表现无显著差异。绿茶提取物显著改善了老年大鼠的学习和记忆能力，在被动回避试验中进入差异的保留潜伏期增加。在高架迷宫试验中，绿茶处理使年轻和老年大鼠进入封闭臂的次数显著增多。与绿茶处理的年轻大鼠相比，绿茶处理的老年大鼠大脑中乙酰胆碱酯酶活性下降。