Samánek M, Slavík Z, Krejcír M
Cardiocentre, Faculty Hospital, Prague.
Czech Med. 1991;14(3):146-55.
The incidence of congenital heart defects was studied prospectively in all 664 218 children born in 1977 to 1984. Those suspected of having a heart disease were examined at the centre specialized in pediatric cardiology. All children who died were autopsied and those where a heart defect was proved were included in our series. In total, 4409 infants (6,64/1000 live births) were born with a heart defect in Bohemia. Differences from one year to another were not statistically significant. The incidence of infants with a heart defect was highest in October, lowest in December, June and July (p less than 0.05). Seasonal incidence of individual forms of heart defects differed also. The seasonal variation was not influenced by the total number of live births. The high incidence of congenital heart defects in infants born in October and November coincides with the epidemics of influenza in early pregnancy.
对1977年至1984年出生的664218名儿童进行了先天性心脏缺陷发病率的前瞻性研究。那些疑似患有心脏病的儿童在专门的儿科心脏病中心接受检查。所有死亡儿童均进行了尸检，那些被证实患有心脏缺陷的儿童被纳入我们的研究系列。在波希米亚，共有4409名婴儿（每1000例活产中有6.64例）患有心脏缺陷。各年份之间的差异无统计学意义。患有心脏缺陷的婴儿发病率在10月最高，在12月、6月和7月最低（p<0.05）。各种类型心脏缺陷的季节性发病率也有所不同。季节性变化不受活产总数的影响。10月和11月出生的婴儿先天性心脏缺陷发病率较高，这与早孕期流感流行相吻合。
