Fujisawa Takashi, Sano Wataru, Ouchi Sachiko, Ueyama Shigemitsu, Mori Toshiyuki, Tsuchihashi Daisuke, Uchikoga Osamu, Koyanagi Maki, Yoshimura Hisashi, Tachibana Shiro, Hirano Hirotsugu
Dept. of Internal Medicine, Nippon Steel Hirohata Hospital.
Gan To Kagaku Ryoho. 2007 Dec;34(13):2297-300.
A 60-year-old man complaining of black stool, body weight loss, and anemia, was examined and diagnosed with advanced gastric cancer (M, type 3, por 2, cT3, cN3, cH0, cP0, cM0, cStage IV). A poor prognosis was predicted, yet we tried neoadjuvant chemotherapy (NAC) expecting downstaging of the tumor. Considering the efficacy and safety, we chose S-1+CDDP as the NAC regimen. S-1 (120 mg/day) was administered orally for 21 days, followed by CDDP (75 mg/body) div on day 8. Distal partial gastrectomy and lymph node dissection (D2) were performed, with Billroth I reconstruction. Histological examination of the resected stomach and lymph nodes revealed no residual cancer cells, suggesting complete histological remission (grade 3) according to the Japanese classification of gastric carcinoma.
一名60岁男性，因黑便、体重减轻和贫血前来就诊，经检查被诊断为晚期胃癌（M，3型，por 2，cT3，cN3，cH0，cP0，cM0，cStage IV）。尽管预计预后较差，但我们仍尝试进行新辅助化疗（NAC）以期使肿瘤降期。考虑到疗效和安全性，我们选择S-1+顺铂作为NAC方案。S-1（120毫克/天）口服给药21天，随后在第8天给予顺铂（75毫克/体）分剂量给药。行远端胃部分切除术及淋巴结清扫（D2），采用毕Ⅰ式重建。对切除的胃和淋巴结进行组织学检查，未发现残留癌细胞，根据日本胃癌分类提示完全组织学缓解（3级）。
