Brown James S, Graham Judith A, Chen Lung Chi, Postlethwait Edward M, Ghio Andrew J, Foster W Michael, Gordon Terry
National Center for Environmental Assessment, U.S. Environmental Protection Agency, RTP, North Carolina 27711, USA.
J Expo Sci Environ Epidemiol. 2007 Dec;17 Suppl 2:S97-105. doi: 10.1038/sj.jes.7500632.
In December 2006, the U.S. Environmental Protection Agency (EPA) sponsored a 2-day workshop on "Interpretation of Epidemiologic Studies of Multipollutant Exposure and Health Effects" in Chapel Hill, NC. The final session at this workshop was devoted to assessing the biological plausibility of epidemiological findings with regard to criteria air pollutants. The presentations and the panel contributions of this last session primarily focused on controlled exposure studies and led to wide-ranging discussions, some of which were provocative. The panel summary provides some guidance to future evaluations of the biological plausibility of the epidemiological reports on criteria pollutants and is intended to stimulate thinking, without drawing any definitive conclusions. This paper does not approach, nor was it intended to approach, the more formal analytical approach such as that used in EPA's development of its Science Assessment Document for the criteria pollutants.
2006年12月，美国环境保护局（EPA）在北卡罗来纳州教堂山举办了一场为期两天的关于“多污染物暴露与健康影响的流行病学研究解读”的研讨会。本次研讨会的最后一场会议专门评估了关于标准空气污染物的流行病学研究结果在生物学上的合理性。最后一场会议的报告和专家小组发言主要聚焦于对照暴露研究，并引发了广泛讨论，其中一些讨论颇具启发性。专家小组总结为未来评估关于标准污染物的流行病学报告在生物学上的合理性提供了一些指导，旨在激发思考，而不做任何定论。本文并非采用，也无意采用EPA在制定标准污染物科学评估文件时所使用的那种更正式的分析方法。
