Top C, Sahan B, Onde M E
Department of Internal Medicine, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Istanbul, Turkey.
J Int Med Res. 2007 Nov-Dec;35(6):909-16. doi: 10.1177/147323000703500621.
The relationship between left ventricular mass index (LVMI) and insulin sensitivity, postprandial glycaemia, fasting serum triglyceride and adiponectin was investigated in 70 patients with type 2 diabetes. Serum fasting insulin, C-peptide, high-sensitivity C-reactive protein (hs-CRP), glycated haemoglobin (HbA1c), postprandial glycaemia, lipids and fasting serum adiponectin levels were measured. Ventricular hypertrophy was assessed at rest by electrocardiography and echocardiography. Insulin sensitivity was assessed using the homeostasis model assessment index (HOMA-IR). LVMI was assessed using the Devereux formula. Study patients had lower than normal HOMA-IR, and higher than normal serum fasting insulin levels and LVMI, and tended to have reduced insulin sensitivity. Pearson's correlation coefficient showed a statistically significant correlation between fasting serum adiponectin and LVMI, fasting serum insulin, HOMA-IR, HbA1c, serum postprandial glucose and hs-CRP. There were no statistically significant correlations between LVMI and serum hs-CRP or HOMA-IR. The results indicate the importance of fasting serum adiponectin in the development of cardiovascular complications, such as increased LVMI.
在70例2型糖尿病患者中研究了左心室质量指数（LVMI）与胰岛素敏感性、餐后血糖、空腹血清甘油三酯和脂联素之间的关系。测定了血清空腹胰岛素、C肽、高敏C反应蛋白（hs-CRP）、糖化血红蛋白（HbA1c）、餐后血糖、血脂和空腹血清脂联素水平。通过心电图和超声心动图在静息状态下评估心室肥厚。使用稳态模型评估指数（HOMA-IR）评估胰岛素敏感性。使用Devereux公式评估LVMI。研究患者的HOMA-IR低于正常，空腹血清胰岛素水平和LVMI高于正常，且胰岛素敏感性有降低趋势。Pearson相关系数显示空腹血清脂联素与LVMI、空腹血清胰岛素、HOMA-IR、HbA1c、血清餐后血糖和hs-CRP之间存在统计学显著相关性。LVMI与血清hs-CRP或HOMA-IR之间无统计学显著相关性。结果表明空腹血清脂联素在心血管并发症（如LVMI增加）发生发展中的重要性。
