Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, ST816, Boston, Massachusetts 02115, USA.
Eur J Endocrinol. 2010 Feb;162(2):281-8. doi: 10.1530/EJE-09-0555. Epub 2009 Nov 17.
Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfunction, and/or insulin secretion or insulinemia.
We studied 1065 healthy women, Nurses' Health Study participants, who provided blood samples in 1989-1990. A cross-sectional analysis was conducted to assess the relationships between total and high-molecular weight (HMW) adiponectin and resistin with inflammatory markers and biomarkers of endothelial dysfunction, insulin secretion, and insulinemia.
Resistin was positively associated with the inflammatory markers soluble tumour necrosis factor-alpha receptor II and interleukin-6 but not with any biomarkers of endothelial function, glycemia, insulinemia, or markers of insulin secretion after multivariate adjustment for age and body mass index (BMI). In both crude and multivariate analyses, total adiponectin was inversely associated with insulin, proinsulin, C-peptide, HbA1c, sE-selectin, and C-reactive protein (CRP) levels. HMW adiponectin was inversely associated with circulating insulin, proinsulin, C-peptide, HbA1c, sE-selectin, and CRP concentrations, even after adjustment for age, BMI, lifestyle factors, exercise, the use of medications as well as the other biomarkers of interest. Total and HMW adiponectin demonstrated negative associations with soluble intercellular adhesion molecule-1, which became nonsignificant after adjustment for confounders, whereas positive associations between soluble vascular cell adhesion molecule-1 and total adiponectin became significant only after multivariate adjustment.
Total and HMW adiponectin are inversely associated with markers of insulin secretion/insulinemia, endothelial function, and inflammation. Resistin is positively associated only with markers of inflammation.
脂联素和抵抗素与炎症、内皮功能障碍和/或胰岛素分泌或抵抗有关。目前尚不清楚这些脂肪因子中哪一种主要与所有或仅部分这些类别（即炎症标志物、内皮功能障碍标志物和/或胰岛素分泌或胰岛素血症标志物）的生物标志物相关。
我们研究了 1989-1990 年提供血液样本的 1065 名健康女性（护士健康研究参与者）。进行了一项横断面分析，以评估总脂联素和高分子量（HMW）脂联素与抵抗素与炎症标志物以及内皮功能障碍、胰岛素分泌和胰岛素血症的生物标志物之间的关系。
抵抗素与炎症标志物可溶性肿瘤坏死因子-α受体 II 和白细胞介素-6 呈正相关，但与内皮功能、血糖、胰岛素血症或胰岛素分泌标志物无关，经年龄和体重指数（BMI）多变量调整后。在未经调整和多变量分析中，总脂联素与胰岛素、胰岛素原、C 肽、HbA1c、sE-选择素和 C 反应蛋白（CRP）水平呈负相关。HMW 脂联素与循环胰岛素、胰岛素原、C 肽、HbA1c、sE-选择素和 CRP 浓度呈负相关，即使在调整年龄、BMI、生活方式因素、运动、药物使用以及其他感兴趣的生物标志物后也是如此。总脂联素和 HMW 脂联素与可溶性细胞间黏附分子-1 呈负相关，在调整混杂因素后变得无统计学意义，而可溶性血管细胞黏附分子-1 与总脂联素之间的正相关在多变量调整后才变得显著。
总脂联素和 HMW 脂联素与胰岛素分泌/胰岛素血症、内皮功能和炎症标志物呈负相关。抵抗素仅与炎症标志物呈正相关。
