Abiko Yoshihiro, Saitoh Masto, Nishimura Michiko, Yamazaki Mami, Sawamura Daisuke, Kaku Tohru
Department of Dental Science, Division of Oral Medicine and Pathology, Institute of Personalized Medical Science, Health Sciences University of Hokkaido, 2-5 Ainosato, Kita-ku, Sapporo, Hokkaido, Japan.
Med Mol Morphol. 2007 Dec;40(4):179-84. doi: 10.1007/s00795-007-0381-8. Epub 2007 Dec 21.
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. beta-Defensins are a group of antimicrobial peptides mainly produced by epithelial cells of many organs including skin, lung, kidney, pancreas, uterus, eye, and nasal and oral mucosa. This review focuses on beta-defensins (BDs) in oral epithelia and discusses their importance in oral epithelial health and disease. BDs exhibit antimicrobial activity against oral microbes including periodontitis-related bacteria, Candida, and papilloma virus. Alterative expression of BDs was observed in oral epithelial diseases, including oral inflammatory lesions with and without microbial infection and oral cancer. BDs may be useful in the treatment of oral infectious diseases, ulcerative lesions, and cancer. BDs play an important role in protection against oral microbes and may be used in clinical applications.
口腔上皮作为一种机械性和保护性屏障，可抵抗细菌感染。β-防御素是一类主要由包括皮肤、肺、肾、胰腺、子宫、眼睛以及鼻腔和口腔黏膜在内的许多器官的上皮细胞产生的抗菌肽。本综述聚焦于口腔上皮中的β-防御素（BDs），并讨论它们在口腔上皮健康和疾病中的重要性。BDs对包括牙周炎相关细菌、念珠菌和乳头瘤病毒在内的口腔微生物具有抗菌活性。在口腔上皮疾病中观察到BDs的表达改变，包括有或无微生物感染的口腔炎性病变以及口腔癌。BDs可能在口腔传染病、溃疡性病变和癌症的治疗中发挥作用。BDs在抵御口腔微生物方面发挥重要作用，并且可能用于临床应用。
