Abiko Yoshihiro, Nishimura Michiko, Kaku Tohru
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
Med Electron Microsc. 2003 Dec;36(4):247-52. doi: 10.1007/s00795-003-0225-0.
Saliva contains several types of antimicrobial peptides that play a role in innate immunity. Peptides that were recently added to this list are the defensins. The purpose of this review is to summarize what is known about the production and role of defensins in the salivary glands and to discuss their therapeutic potential. The Alpha-defensins, human neutrophil defensins (HNP)-1, -2, and -3, have been detected in saliva and may be derived from neutrophils. The Beta-defensins, human Beta-defensins (HBD)-1 and -2, have also been detected in saliva. Although it has been speculated that salivary HBDs are derived from keratinocytes that line the oral mucosa rather than from the salivary glands, the HBD-1 peptide was recently found to be specifically expressed in salivary ductal cells, although not in acini. Defensins may be useful for the treatment of periodontal disease and for the prevention of caries and periodontitis.
唾液中含有多种抗菌肽，它们在先天免疫中发挥作用。最近被列入这一名单的肽类是防御素。本综述的目的是总结关于防御素在唾液腺中的产生和作用的已知信息，并讨论它们的治疗潜力。α-防御素，即人类中性粒细胞防御素（HNP）-1、-2和-3，已在唾液中被检测到，可能来源于中性粒细胞。β-防御素，即人类β-防御素（HBD）-1和-2，也已在唾液中被检测到。尽管有人推测唾液中的HBDs来源于口腔黏膜的角质形成细胞而非唾液腺，但最近发现HBD-1肽在唾液导管细胞中特异性表达，而在腺泡细胞中不表达。防御素可能对治疗牙周疾病以及预防龋齿和牙周炎有用。
