Froom S R, Cann C, Wilkes A R, Gildersleve C, Hall J E
Department of Anaesthetics and Intensive Care Medicine, University Hospital of Wales, and Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Anaesthesia. 2008 Jan;63(1):77-81. doi: 10.1111/j.1365-2044.2007.05277.x.
The aim of this study was to determine the filtration performance of five commonly used paediatric breathing system filters following exposure to desflurane, isoflurane and sevoflurane. It has been suggested that oil may degrade the performance of filter material. Volatile anaesthetic vapours are organic and hence may affect the filtration performance of breathing system filters during anaesthesia. This has not been tested for various concentrations of volatile agent, type and duration of exposure. The filtration performance of the filters was measured following exposure to desflurane, isoflurane and sevoflurane at 1 and 2 minimum alveolar concentration (MAC) for 1 and 4 h. Penetration of particles through the Clear-Therm Micro, Clear-Therm Mini and Humid-Vent Filter Pedi increased by between 2.4 and 2.8 times after exposure to desflurane at 2 MAC for 4 h compared to that through unexposed filters (p < 0.0001 for all three filters). Further investigation is required to determine whether this reduction in filtration performance by desflurane is clinically significant.
本研究的目的是确定五种常用儿科呼吸过滤器在接触地氟烷、异氟烷和七氟烷后的过滤性能。有人提出，油可能会降低过滤材料的性能。挥发性麻醉蒸汽是有机的，因此可能会影响麻醉期间呼吸过滤器的过滤性能。但尚未针对不同浓度的挥发性药物、暴露类型和持续时间进行测试。在接触地氟烷、异氟烷和七氟烷1和2最低肺泡浓度（MAC）1小时和4小时后，测量过滤器的过滤性能。与未暴露的过滤器相比，在2 MAC下接触地氟烷4小时后，Clear-Therm Micro、Clear-Therm Mini和Humid-Vent Filter Pedi过滤器的颗粒穿透率增加了2.4至2.8倍（所有三种过滤器p < 0.0001）。需要进一步研究以确定地氟烷导致的这种过滤性能降低是否具有临床意义。
