Gorski R J, Plasz A C, Elrod L, Yoder J, White L B
Analytical Research Department, Abbott Laboratories, North Chicago, Illinois 60064-4000.
Pharm Res. 1991 Dec;8(12):1525-7. doi: 10.1023/a:1015850517994.
Cefsulodin, cefmenoxime, and cefadroxil are degraded instantaneously in aqueous sodium hypochlorite, sodium hypochlorite-detergent, or alkaline detergent solutions. These alkaline solutions are used to clean surfaces that have been exposed to the cephalosporins. The cleaned surfaces are monitored for residual drug levels (microgram) using a wet swab-dry swab technique. After extraction from the swabs, the content of the respective cephalosporin is determined in the solution by high-performance liquid chromatography. The limit of detection for each of the compounds is 0.1 microgram/ml. Recoveries from nonporous surfaces ranged from 56 to 102%.
头孢磺啶、头孢甲肟和头孢羟氨苄在次氯酸钠水溶液、次氯酸钠洗涤剂溶液或碱性洗涤剂溶液中会立即降解。这些碱性溶液用于清洁接触过头孢菌素的表面。使用湿拭子-干拭子技术监测清洁后的表面残留药物水平（微克）。从拭子中提取后，通过高效液相色谱法测定溶液中各头孢菌素的含量。每种化合物的检测限为0.1微克/毫升。从无孔表面的回收率在56%至102%之间。
