Marcellin Patrick, Pequignot Françoise, Delarocque-Astagneau Elisabeth, Zarski Jean-Pierre, Ganne Nathalie, Hillon Patrick, Antona Denise, Bovet Martine, Mechain Murielle, Asselah Tarik, Desenclos Jean-Claude, Jougla Eric
Service d'Hépatologie & INSERM CRB3, University of Paris VII, AP-HP, CHU Beaujon, Clichy, France.
J Hepatol. 2008 Feb;48(2):200-7. doi: 10.1016/j.jhep.2007.09.010. Epub 2007 Nov 20.
BACKGROUND/AIMS: Mortality related to HCV and HBV infections was estimated in France.
A random sample (n=999) of death certificates was obtained from all death certificates listing HBV, HCV, hepatitis, liver disease, possible complication of cirrhosis, bacterial infection, HIV, or transplantation (n=65,000) in France in 2001. Physicians who reported the deaths were sent a questionnaire to identify how many deaths were related to HBV/HCV infection. Completed forms were independently analyzed by a panel of hepatologists. Death rates were estimated according to national population census data.
Estimated annual number of deaths associated with HCV and HBV infection was 3618 and 1507, respectively (6.1 and 2.5 deaths per 100,000 inhabitants, respectively). Estimated number of deaths attributable to HCV or HBV infection was 2646 and 1327, respectively (4.5 and 2.2 deaths per 100,000 inhabitants, respectively). In the HCV infection group, 95 percent had cirrhosis; 33 percent had hepatocellular carcinoma (HCC). In the HBV infection group, 93 percent had cirrhosis; 35 percent had HCC. Eleven percent of deaths occurred in patients with HIV coinfection. Deaths related to HBV or HCV infection occurred at an earlier age in patients with a history of excessive alcohol consumption.
In France, 4000-5000 deaths related to HCV and HBV infection occurred in 2001. Alcohol consumption and HIV infection were important co-factors. These data emphasize the need for ongoing, efficient public health programs that include screening, management, and counseling for HCV- and HBV-infected individuals.
背景/目的：对法国丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）感染相关的死亡率进行估算。
从2001年法国所有列出HBV、HCV、肝炎、肝病、肝硬化可能并发症、细菌感染、HIV或移植的死亡证明（共65,000份）中随机抽取999份死亡证明样本。向报告死亡情况的医生发送问卷，以确定与HBV/HCV感染相关的死亡人数。由一组肝病专家对填写完整的表格进行独立分析。根据全国人口普查数据估算死亡率。
与HCV和HBV感染相关的年死亡人数估计分别为3618人和1507人（每10万居民中分别有6.1人和2.5人死亡）。归因于HCV或HBV感染的死亡人数估计分别为2646人和1327人（每10万居民中分别有4.5人和2.2人死亡）。在HCV感染组中，95%的患者患有肝硬化；33%的患者患有肝细胞癌（HCC）。在HBV感染组中，93%的患者患有肝硬化；35%的患者患有HCC。11%的死亡发生在合并HIV感染的患者中。有过量饮酒史的患者中，与HBV或HCV感染相关的死亡发生年龄更早。
2001年在法国，有4000 - 5000人死于与HCV和HBV感染相关的疾病。饮酒和HIV感染是重要的共同因素。这些数据强调了开展持续有效的公共卫生项目的必要性，这些项目应包括对HCV和HBV感染者的筛查、管理及咨询。
