Sánchez-Rodríguez Martha A, Ruiz-Ramos Mirna, Correa-Muñoz Elsa, Mendoza-Núñez Víctor Manuel
Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), México DF, México.
BMC Musculoskelet Disord. 2007 Dec 19;8:124. doi: 10.1186/1471-2474-8-124.
Oxidative stress (OxS) has recently been linked with osteoporosis; however, we do not know the influence of OxS as an independent risk factor for this disease.
We conducted a case-control study in 94 subjects > or =60 years of age, 50 healthy and 44 with osteoporosis. We measured total antioxidant status, plasma lipid peroxides, antioxidant activity of superoxide dismutase and glutathione peroxidase (GPx), and calculated the SOD/GPx ratio. Bone mineral density was obtained at the peripheral DXA in calcaneus using a portable Norland Apollo Densitometer. Osteoporosis was considered when subjects had a BMD of 2.5 standard deviations or more below the mean value for young adults.
GPx antioxidant activity was significantly lower in the group of subjects with osteoporosis in comparison with the group of healthy subjects (p < 0.01); in addition, the SOD/GPx ratio was significantly higher in the group of individuals with osteoporosis (p < 0.05). In logistic regression analysis, we found OxS to be an independent risk factor for osteoporosis (odds ratio [OR] = 2.79; 95% confidence interval [95% CI] = 1.08-7.23; p = 0.034).
Our findings suggest that OxS is an independent risk factor for osteoporosis linked to increase of SOD/GPx ratio.
氧化应激（OxS）最近被认为与骨质疏松症有关；然而，我们尚不清楚氧化应激作为该疾病的独立危险因素所产生的影响。
我们对94名年龄≥60岁的受试者进行了一项病例对照研究，其中50名健康受试者，44名患有骨质疏松症。我们测量了总抗氧化状态、血浆脂质过氧化物、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的抗氧化活性，并计算了SOD/GPx比值。使用便携式Norland Apollo骨密度仪通过外周双能X线吸收法（DXA）测量跟骨的骨密度。当受试者的骨密度比年轻人的平均值低2.5个标准差或更多时，即被认为患有骨质疏松症。
与健康受试者组相比，骨质疏松症受试者组的GPx抗氧化活性显著降低（p<0.01）；此外，骨质疏松症患者组的SOD/GPx比值显著更高（p<0.05）。在逻辑回归分析中，我们发现氧化应激是骨质疏松症的独立危险因素（比值比[OR]=2.79；95%置信区间[95%CI]=1.08 - 7.23；p = 0.034）。
我们的研究结果表明，氧化应激是与SOD/GPx比值升高相关的骨质疏松症的独立危险因素。
