Swift Arthur, von Grote Erika, Jonas Brandie, Nogueira Alessandra
Arthur Swift Research Inc., Montreal, QC, Canada.
Medical Affairs, Galderma Laboratories, L.P., Fort Worth, TX, USA.
Clin Cosmet Investig Dermatol. 2017 Jun 14;10:229-238. doi: 10.2147/CCID.S138155. eCollection 2017.
The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients.
A single-center, noncomparative study evaluated the time (in hours) until subjects return to social engagement (RtSE) following correction of moderate and severe nasolabial folds (NLFs) with R (Restylane Refyne) and R (Restylane Defyne), respectively. Twenty subjects (aged 35-57 years) who received bilateral NLF correction documented their RtSE and injection-related events posttreatment. Treatment efficacy was evaluated by improvements in Wrinkle Severity Rating Scale (WSRS) and subject satisfaction questionnaire at days 14 and 30, and by Global Aesthetic Improvement Scale (GAIS) at day 30. Safety was evaluated by injection-related events and treatment-emergent adverse events.
Fifty percent of subjects reported RtSE within 2 hours posttreatment. WSRS for the R group improved significantly from baseline at day 14 (-1.45±0.42) and day 30 (-1.68±0.46) (<0.001), respectively. WSRS for the R group improved significantly from baseline at day 14 (-2.22±0.44) and day 30 (-2.50±0.50) (<0.004), respectively. All GAIS improvements were clinically significant at day 30. The majority of injection-related events were mild or moderate. Two subjects experienced 3 related treatment-emergent adverse events; 1 R subject experienced severe bruising, and 1 R subject experienced severe erythema and mild telangiectasia. Subject satisfaction was high regarding aesthetic outcomes and natural-looking results.
Optimal correction of moderate NLFs with R and severe NLFs with R involved minimal time to RtSE for most subjects. Treatments that significantly improved WSRS and GAIS, were generally well-tolerated, and provided natural-looking aesthetic outcomes.
透明质酸填充剂用于面部软组织填充的吸引力既在于即时的美学效果，也在于相对较短的恢复时间。尽管恢复时间是治疗后的一个重要变量，因为它会影响外观舒适度和感知到的治疗益处，但并未常规进行评估。自然美观的美学效果也是许多患者的主要关注点。
一项单中心、非对照研究评估了分别使用瑞蓝丽瑅（Restylane Refyne）和瑞蓝唯瑅（Restylane Defyne）矫正中度和重度鼻唇沟（NLF）后受试者恢复社交活动（RtSE）所需的时间（以小时为单位）。20名年龄在35至57岁之间接受双侧鼻唇沟矫正的受试者记录了他们治疗后的RtSE及与注射相关的事件。在第14天和第30天通过皱纹严重程度评定量表（WSRS）和受试者满意度问卷评估治疗效果，在第30天通过整体美学改善量表（GAIS）评估。通过与注射相关的事件和治疗中出现的不良事件评估安全性。
50%的受试者在治疗后2小时内报告恢复社交活动。瑞蓝丽瑅组的WSRS在第14天（-1.45±0.42）和第30天（-1.68±0.46）分别从基线显著改善（<0.001）。瑞蓝唯瑅组的WSRS在第14天（-2.22±0.44）和第30天（-2.50±0.50）分别从基线显著改善（<0.004）。在第30天所有GAIS改善均具有临床意义。大多数与注射相关的事件为轻度或中度。两名受试者经历了3次与治疗相关的不良事件；1名瑞蓝丽瑅受试者出现严重瘀伤，1名瑞蓝唯瑅受试者出现严重红斑和轻度毛细血管扩张。受试者对美学效果和自然外观结果的满意度较高。
对于大多数受试者，使用瑞蓝丽瑅矫正中度鼻唇沟和使用瑞蓝唯瑅矫正重度鼻唇沟能使恢复社交活动的时间最短。这些治疗能显著改善WSRS和GAIS，通常耐受性良好，并能提供自然美观的美学效果。
